Personalized treatment of early-stage breast cancer: Present concepts and future directions |
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Authors: | Nadia Harbeck Marwa Salem Ulrike Nitz Oleg Gluz Cornelia Liedtke |
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Institution: | 1. Breast Center, Department of Gynecology and Obstetrics, University Hospital Köln, Cologne, Germany;2. West German Study Group (WSG), Mönchengladbach, Germany;3. Bethesda Hospital Wuppertal, Wuppertal, Germany;4. Department of Gynecology and Obstetrics, University Hospital Münster, Münster, Germany |
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Abstract: | Breast cancer is the most common malignancy in women. Effective loco-regional as well as systemic treatment options have rendered breast cancer a curable disease for the vast majority of early-stage patients. Considering tumor biology and clinical outcomes, breast cancer is a very heterogeneous disease. With the recent understanding of distinct molecular sub-types, the era of “one size fits all” therapy concepts has passed and a new era of personalized therapy concepts has started. This review will focus on recent advances in personalized treatment of early-stage breast cancer, with a particular interest in tumor biology-guided treatment decisions. It will also highlight how carefully molecular tests need to be methodologically and clinically validated before they can be applied for clinical decision making. |
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Keywords: | Predictive factor Prognostic factor Personalized treatment Breast cancer Patient stratification |
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