动脉内灌注尿激酶治疗血管性突发性耳聋初探

目的采用动脉内局部药物灌注对血管性突发性感音神经性耳聋患者进行探索性治疗。方法将41例突发性感音神经性耳聋患者随机分为两组，动脉组19例，均行全脑血管造影，将导管置于椎动脉开口，选用尿激酶30万U于30min注射完毕；常规治疗组22例，采用静脉途径给予活血、解痉药物治疗。对两组患者的疗效进行比较，疗效标准采用1997中华医学会耳鼻咽喉科学会颁布的疗效分级。结果动脉组患者痊愈9例，显效5例，有效3例，无效2例；静脉组患者痊愈4例，显效2例、有效9例，无效7例。结论动脉内局部药物灌注可能是治疗突发性感音神经性耳聋的有效治疗方法。

Preliminary study on intra-arterial urokinase infusion in patients with vascular sudden deafness

Objective To study the therapeutic effect of intra-arterial infusion of thrombolytic agents for patients with sudden sensorineural hearing loss. Methods 41 patients were assigned to two groups. In the intra-arterial infusion group, 19 cases were infused 300 000 unit Urokinase via vertebral artery within 30 minutes. In control group, 22 patients were treated intravenously. The criterion of therapeutic effect formulated by Chinese Association of Otorhinolaryngology in 1997 was used to evaluate the therapeutic effect. Results In the intra-arterial group, 9 of 19 were healed completely. Improvement of hearing loss were observed in 8 cases, among them, 5 showed marked improvement. No improvement in 2 patients. In the control group, 4 patients recovered. 11 improved, 2 of then showed marked improvement. No improvement in 7. Conclusion Intra-arterially regional infusion of thrombolytic agents may become a new and effective treatment for the patients with sudden sensorineural hearing loss.