慢性乙型肝炎患者血清sVCAM-1与年龄、舌色关系研究

目的：该研究对慢性乙型肝炎血清可溶性血管细胞黏附分子-1（soluble vascular cell adhesionmolecule-1,sVCAM-1）进行检测,分析其与中医舌色和患者年龄的关系,从黏附分子角度探求慢乙肝中医舌色的病理基础,为临床治疗提供参考。方法：选择2011年11月—2011年12月首都医科大学附属北京中医医院肝病门诊就诊的慢性乙型肝炎患者180例为研究对象,并与150例健康人作为对比,观察患者的舌色并记录其他四诊信息,同时采用ELISA方法检测患者血清sVCAM-1水平,并记录患者肝功能、病毒指标和肝脏B超检查结果,所有数据输入SPSS 11.5统计软件,进行方差分析、卡方检验等统计分析。结果：慢乙肝患者以黯、紫舌多见,随年龄增大、病程延长,黯、紫舌明显增多,50岁后,患者以紫舌为主,提示舌色与患者病程密切相关;紫舌患者较淡红舌、黯舌患者血清sVCAM-1增高,差异有统计学意义（P〈0.05）,提示紫舌的形成机理与血清sVCAM-1增高相关。结论：慢性乙型肝炎舌色有一定的演变规律,血清sVCAM-1的升高是形成慢乙肝紫舌的病理基础之一。

Research on Relationship Between Serum sVCAM- 1 and Age Tongue Colour in Chronic Hepatitis B Patients

Objective： To discuss the relationship between serum sVCAM- 1 and age, tongue colour in chronic hepatitis B patients. Methods ： 180 outpatient cases with chronic hepatitis B and 150 healthy human subjects were analyzed, the tongue colour was observed by doctors; the syndrome was analyzed ; serum sVCAM-1 was determined by ELISA. All data was processed by SPSSll.5. Results： Most patients with chronic hepatitis had dark or purple tongue. With the age and course of chronic hepatitis B increasing, the dark and purple tongue became more significant. After 50 years old, most patients had purple tongue. The patients with purple tongue had elevated serum sVCAM-1 than those with pink tongue, dark tongue, the difference was significant （ P〈0.05 ）. Conclusion ： The serum sVCAM-1 is closely correlated with purple tongue in chronic hepatitis B patients.