清热通下法治疗急性胆源性感染机制探讨

急性胆源性感染包括急性胆囊炎、急性梗阻性化脓性胆管炎、急性胆源性胰腺炎等,是胆道外科临床常见的一种急腹症,主要症状有突发右上腹持续性疼痛,阵发性加剧,可向右肩背部放射,伴有恶心呕吐、寒战发热,或黄疸等,重症感染时可导致全身炎症反应综合征,继而发生器官功能障碍,甚至脏器功能衰竭,尽管临床上有抗感染、抗休克、外科手术干预等综合疗法,但疗效不尽人意。经过多年临床实践,清热通下中医药疗法治疗急性胆源性感染已趋于成熟,尽管其作用的分子机制仍未完全阐明,但其临床疗效不容小觑,现对其治疗急性胆源性感染中的机制探讨如下。

Exploration on Method of Clearing Heat and Purgation in Treating Acute Biliary Infection

The acute biliary infection includes acute cholecystitis, acute obstructive suppurative cholangitis and acute gallstone pancreatitis, and it is a common acute abdomen problem. The symptoms are mainly sudden persistent pain in right upper abdomen with paroxysmal intensification radiating to the right shoulder and back, accompanied by nausea, vomiting, chills, fever or jaundice. Severe infections can lead to systemic inflammatory response syndrome and subsequent organ dysfunction, and even organ failure. Despite clinical therapies such as anti-infective, anti-shock, surgical intervention, the effects are less than satisfactmy. After years of clinical practice, method of clearing heat and purgation in treating acute biliary infection becomes mature. Despite its role in the molecular mechanisms has not been fully elucidated yet, its clinical efficacy can not be underestimated, and now the mechanism of treating acute biliary will be mentioned next.