活血疏肝解郁法对脑卒中后抑郁患者血清NSE的影响

目的：观察活血疏肝解郁法治疗脑卒中后抑郁（PSD）的临床疗效。方法：将50例PSD患者随机分为治疗组和对照组,每组25例。对照组口服盐酸氟西汀治疗,治疗组在此基础上给予活血疏肝解郁汤口服及足浴1号方浸足,两组均同时进行心理干预,疗程为8周。观察两组的汉密尔顿抑郁量表（HAMD）评分、神经功能缺损评分（NIHSS）及血清NSE水平的变化。结果：治疗组和对照组的HAMD评分改善的总有效率分别为92%和76%,治疗组疗效优于对照组（P〈0.05）。治疗后,两组患者的HAMD评分、NIHSS评分及血清NSE水平较治疗前均显著降低（P〈0.01）,且治疗组的HAMD评分、NIHSS评分及血清NSE水平较对照组降低更加显著（P〈0.05）。结论：活血疏肝解郁法治疗脑卒中后抑郁可改善患者的抑郁症状及神经功能缺损状况,降低患者的血清NSE水平。

Effect of Activating Blood,Dispersing Liver and Relieving Depression Method on Serum Neuron-specific Enolase of Patients with Post-stroke Depression

Objective： To observe the clinical efficacy of activating blood,dispersing liver and relieving depression method in the treatment of post-stroke depression（PSD）.Methods： Fifty patients with PSD were randomized into two groups： the control group in which 25 cases were treated by fluoxertine hydrochloride and the treatment group in which 25 cases were treated by fluoxertine hydrochloride,＂Activating-blood,Dispersing-liver and Relieving-depression Recipe＂ and＂Zhuyu No.1 Recipe＂.All the patients accepted the psychologic intervention.The course of treatment was 8 weeks.The Hamilton Depression Scale（HAMD） score,National Institute of Health Stroke Scale（NIHSS） score and the level of neuron-specific enolase（NSE） were observed.Results： The total effective rates of treatment group and control group on the improvement of HAMD scores were 92% and 76% respectively,with a statistical difference between the two groups（P0.05）.After treatment,the HAMD score,NIHSS score and the level of serum NSE were decreased significantly in both groups（P0.01）,and the HAMD score,NIHSS score and the level of serum NSE of treatment group were lower than those of control group（P0.05）.Conclusion： Activating blood,dispersing liver and relieving depression method can improve the depression symptoms and nerve function in patients with PSD,and reduce the level of serum NSE.