通痹饮合剂对大鼠佐剂性关节炎实验研究

目的：探讨通痹饮合剂治疗类风湿性关节炎的作用。方法：建立Freunds完全佐剂性大鼠关节炎模型,观察通痹饮合剂对大鼠关节肿胀度、血清白细胞介素-1β（IL-1β）、肿瘤坏死因子-α（TNF-α）水平。结果：通痹饮合剂低、高剂量对大鼠Freunds完全佐剂性关节炎的继发性足跖肿胀度均有显著的抑制作用（P〈0.05,或P〈0.01）,可抑制IL-1β、TNF-α的异常升高（P〈0.05,P〈0.05）。结论：肾通痹片可能通过降低佐剂性关节炎大鼠血清中异常增高的IL-1β、TNF-α浓度而发挥抗类风湿关节炎的作用。

Experimental Study of Effects of Tongbiyin Mixture on Rats with Adjuvant Arthritis

Objective： To investigate the effects of Tongbiyin Mixture on rheumatoid arthritis. Methods： The model of arthritis was induced by adjuvant and the influence on the articular swelling degree, serum interleukin-1 β （IL-1β）and tumor necrosis factor-A （TNF-cx ）was observed. Results：The low and high dose of Tongbiyin Mixture could significantly inhibite the secondary footpad swelling degree （ P〈0.05, P〈0.01 ）, the strange high levels of IL-1β and TNF- α were decreased （ P〈0.05, P〈0.05 ）. Conclusion ： Tongbiyin Mixture could reduce the concentrations of serum IL-1β and TNF- α levels and control or inhibit the development of rheumatoid arthritis.