穴位敷贴治疗围绝经期失眠的临床观察

目的：观察穴位敷贴治疗女性围绝经期失眠的临床疗效。方法：将符合纳入标准的60例患者随机分为治疗组和对照组,每组30例。治疗组患者在神阙、气海、足三里穴给予安眠贴敷贴治疗,对照组患者在神阙、气海、足三里穴给予对照贴治疗。观察两组的临床疗效及匹茨堡睡眠质量指数（PSQI）,检测患者的血清雌二醇（E2）、促卵泡刺激素（FSH）、促黄体生成素（LH）水平的变化。结果：治疗后,治疗组的总有效率为93.33%,对照组为53.33%,治疗组疗效优于对照组（P〈0.01）;治疗组患者的PSQI量表评分中睡眠质量、实际睡眠时间、睡眠效率、安眠药物维度的评分及总分较治疗前均显著降低（P〈0.01,P〈0.05）,且治疗组患者的睡眠质量、实际睡眠时间、睡眠效率维度的评分及总分较对照组亦显著降低（P〈0.01,P〈0.05）;治疗组患者的血清E2水平显著升高（P〈0.01）,FSH、LH水平显著降低（P〈0.05）,且治疗组患者的血清E2水平较对照组亦显著升高（P〈0.05）,FSH、LH水平较对照组显著降低（P〈0.05）。结论：穴位敷贴治疗能显著改善围绝经期妇女的睡眠质量及相关临床症状,改善激素水平,调节内分泌。

Clinical Observation of Acupoint Sticking Therapy for Perimenopausal Insomnia

Objective： To observe the clinical efficacy of acupoint sticking therapy for perimenopausal insomnia.Methods： Sixty patients with perimenopausal insomnia were randomized into treatment group and control group with 30 cases in each group.The treatment group was treated with＂Anmian Paste＂ at Shenque（RN 8）,Qihai（RN 6） and Zusanli（ST 36）,and the control group was treated with placebo paste at above acupoints.The clinical effect and Pittsburgh Sleep Quality Index（PSQI） were evaluated,and the levels of serum estradiol（E2）,follicle stimulating hormone（FSH） and luteinizing hormone（LH） were detected.Results：The total effective rates of treatment group and control group were 93.33% and 53.33%,with a statistical difference between the two groups（P0.01）.After treatment,The quality of sleep,actual sleep time,sleep efficiency,hypnotics dimensions scores and the total score of PSQI in treatment group were significantly reduced（P0.01,P0.05）,and the quality of sleep,actual sleep time,sleep efficiency dimensions scores and the total score of treatment group were lower than those of control group（P0.01,P0.05）.After treatment,the level of E2 was increased（P0.01） and the levels of FSH and LH were decreased（P0.05） in treatment group,and the level of E2 of treatment group was higher than that of control group（P0.05） and the levels of FSH and LH of treatment group were lower than those of control group（P0.05）.Conclusion： Acupoint sticking therapy can improve the quality of sleep and clinical symptoms and regulate the levels of hormones for patients with perimenopausal insomnia.