乳腺黏液癌22例临床病理分析

目的探讨乳腺黏液癌的临床病理及免疫组化特点。方法回顾性分析22例乳腺黏液癌患者的临床表现、组织形态、免疫组化及预后。结果所有乳腺黏液癌患者年龄32～73岁,平均52.5岁;肿块直径为1～5.5 cm,平均3.3 cm;病理形态分型中单纯型13例,占59.1%,混合型9例,占40.9%;腋窝淋巴结转移4例,占18.2%。雌激素受体（ER）、孕激素受体（PR）阳性表达与组织分型、淋巴结转移及5年生存率比较差异无统计学意义。C-erbB-2阳性率在单纯型与混合型中存在差异。结论乳腺黏液癌转移率低,预后较好,单纯型较混合型淋巴结转移率低。C-erbB-2阳性以及腋窝淋巴结有无转移是判定乳腺黏液癌预后的重要指标。

Clinical and pathological analysis of 22 cases of mucinous carcinoma of breast

Objective To investigate the clinical pathological and immunohistochemical features of muci- nous carcinoma of breast. Methods The clinical manifestations, histology, immunohistochemistry and prognosis of 22 patients with mucinous carcinoma of breast were retrospectively analyzed. Results All the patients aged 32-73 years old, with an average of 52.5 years old. The diameter of tumor was 1-5.5 cm, 3.3 cm in average. As for patholog- ical type, there were 13 cases simple type （59.1%）, 9 cases of mixed type （40,9%）, and 4 cases of axillary lymph nodemetastasis （18.2%）. Estrogen receptor （ER）, progesterone receptor （PR） expression and the histological type, lymph node metastasis and 5 year survival rate showed no statistically significant difference. The positive rate of C-erbB-2 showed significant difference between the pure type and mixed type. Conclusion Mucinous carcinoma of breast has relatively low metastasis rate and good prognosis, and the simple type has lower metastasis rate than the mixed type. C-erbB-2 positive and axillary lymph node with or without metastasis are important prognostic indicators for the prognosis of mucinous carcinoma of breast.