蜈龙抗癌颗粒治疗小鼠移植性肿瘤的药效学观察

目的:观察蜈龙抗癌颗粒对小鼠移植性肿瘤的治疗效果。方法:采用小鼠移植性肿瘤Lewis肺癌、P388白血病、S180肉瘤和H22肝癌,每个瘤株重复进行3批试验,每批试验用小鼠50只,随机分5组,分别为生理盐水对照组、环磷酰胺(100 mg.kg^-1)组和蜈龙抗癌颗粒低、中、高剂量组,对于Lewis肺癌和P388白血病瘤株,低、中、高剂量分别相当生药10,25,40 g.kg^-1.d^-1,对于S180肉瘤和H22肝癌瘤株,则分别为15,30,50 g.kg^-1.d^-1。观察用药后动物的一般表现、体重增长和肿瘤生长情况。结果:高剂量蜈龙抗癌颗粒对小鼠移植性肿瘤Lewis肺癌、P388白血病、S180肉瘤和H22肝癌的抑制率分别为90.1%,30.8%,49.8%和52.3%。阳性对照药环磷酰胺对以上4种瘤株的抑制率分别为90.6%,77.2%,79.6%和60.3%。高剂量组荷瘤小鼠的体重增长减缓。结论:蜈龙抗癌颗粒对小鼠移植性肿瘤Lewis肺癌、P388白血病、S180肉瘤和H22肝癌均有明显的抑制作用,并呈良好的量效关系。对小鼠Lewis肺癌的治疗效果最明显。高剂量连续用药9~11 d对小鼠有毒性作用。

Pharmacodynamic tests of Wulong Kangai on transplantable tumors in mice

Objective: To observe the pharmacodynamic and side effects of Wulong Kangai,a new drug of Chinese traditional herbal medicine,on 4 strains of mice transplantable tumors.Method: Mice transplantable tumors S180,H22,P388 and Lewis were used in the pharmacodynamic test on the granules of Wulong Kangai.The test on each tumor strain was repeated three times.In each test,50 mice were used and divided into 5 groups.They were negative control group treated by physiological saline,cyclophosphamide control group and 3 test groups treated respectively with Wulong Kangai at deferent dosages of 10,25,40 g·kg^-1·d^-1 in the treatment of Lewis and P388 and 15,30,50 g·kg^-1·d^-1 in the treatment of S180 and H22.Result: The tumor weight were inhibited at the rates of 90.1%,30.8%,49.8% and 52.3% in the mice with tumors of Lewis,P388,S180,and H22 by high dosage of Wulong Kangai as compared with negative control group.The inhibitory rates in cyclophosphamide groups were 90.6%,77.2%,79.6% and 60.3% respectively.The mice body weights grew slower in high dose groups treated by Wulong Kangai granule.Conclusion: Wulong Kangai was effective in treating mice transplantable tumors of Lewis,P388,S180 and H22 with a dose-dependent manner.The Lewis was the most sensitive strain to the drug among the 4 kinds of tested tumors.Side effects appeared during 9-11 days of uninterrupted treatment with high dose Wulong Kangai.