星形细胞在脑损伤中的双向作用

脑损伤后星形细胞会大量增生 ,这些反应性星形细胞可减轻兴奋性氨基酸毒性的损伤 ,缓冲K+ H+ 离子 ,减轻传递抑制 ,对抗氧化损伤和乳酸堆积 ,从而发挥有益的作用。同时 ,这些反应性星形细胞可能参与了脑损伤后的炎症级联反应 ,引起继发性损伤 ,大量增生的星形胶质成为轴突再生和突触重建的障碍 ,从而影响脑损伤后的功能恢复。

Bidirectional Function of Astrocytes in Brain Injury

Astrocytes will la rgely proliferate after brain injury. These reactive astrocytes can decrease the toxic injury of excitatory amino acids and buffer the K+ and H+, reduce tra nsmission inhibition, antagonize oxidative damage and lactate accumulation, thus elaborates its beneficial effect. At the same time, these reactive astrocytes m ay involve in inflammatory cascade reaction after brain injury and cause the sec ondary injury. A large number of the proliferated astrocytes have become the bar rier in axonal regeneration and synaptic reconstruction, which influence the rec overy of function after brain injury.