| 宁夏农村居民不同血糖水平与血清矿物元素的关系 |
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| 引用本文： | 靳雅男,;付海龙,;何俊,;樊学敏,;赵燚,;许红霞,;刘秀英,;张毓洪. 宁夏农村居民不同血糖水平与血清矿物元素的关系[J]. 疾病控制杂志, 2014, 18(8): 744-747 |
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| 作者姓名： | 靳雅男, 付海龙, 何俊, 樊学敏, 赵燚, 许红霞, 刘秀英, 张毓洪 |
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| 作者单位： | [1]宁夏医科大学公共卫生学院流行病与卫生统计学系,宁夏银川750004; [2]宁夏回族自治区人民医院医务科恰好园社区卫生服务站,宁夏银川750001 |
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| 基金项目： | 国家自然科学基金（81160358）;宁夏自然科学基金（NZ1199）;宁夏医科大学“博士学位建设学科”开放课题 |
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| 摘 要： | 目的 比较不同血糖水平下血清中14种矿物质元素含量及血清矿物质元素与血糖水平之间的关系.方法 采用分层整群抽样方法在宁夏4个村中共调查3 391人进行体格检查,采集血液样本1 612例进行血液生化指标的测定,采用电感耦合等离子体发射光谱法(inductively coupled plasma emission spectrometry,ICP-AES)测定l 493例血清中14种矿物质元素的含量.结果 血清Cr表现为正常空腹血糖(normal fasting glucose,NFG)组(6.35±2.75) μg/ml显著高于糖尿病(diabetes mellitus,DM)组(5.47±2.09) μg/ml,Sr为空腹血糖受损(impairedfastimg glucose,IFG)1组(0.13±0.04) μg/ml高于NFG组(0.11±0.05) μg/ml.Cu含量为NFG组(0.99±2.14)μg/ml低于IFG1组(1.00±2.24) μg/ml、IFG 2组(1.03±2.06)μg/ml和DM组(1.07±2.48) μg/ml三组,DM组高于IFG2组.Ga含量为DM组(0.16 ±0.08) μg/ml高于NFG组(0.12±0.08) μg/ml、IFG1组(0.13 ±0.08) μg/ml和IFG2组(0.13±0.08) μg/ml三组.Cu(r=0.083,P=0.017)和Ga(r=0.081,P=0.019)与血糖呈正相关,Cr(r=-0.074,P=0.032)与血糖呈负相关;Cu(r =0.098,P=0.005)和Sr(r=0.087,P=0.012)与胰岛素抵抗指数呈正相关.Cu(OR=1.518,95％ CI:1.072～2.151)和Ca(OR=1.618,95％ CI:1.076～2.432)是血糖异常的危险因素,且Ca位于最高浓度时,血糖异常的风险最高;Sr(OR=0.800,95％ CI:0.678～0.944)是其保护因素.结论 血清铜、镓、铬与血糖水平密切相关,并且铜、锶和钙是血糖异常的独立影响因素.
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| 关 键 词： | 血糖 矿物质 元素 |
The relationship between blood glucose levels and serum mineral elements of rural residents in Ningxia |
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| Affiliation: | JIN Ya- nan , FU Hai-long , lie Jun , FAN Xue-min , ZHAO Yi , XU Hong-xia , LIU Xiu-ying , ZHANG Yu-hong. (1. Department of Epidemiology and Biostatistics, School of Public Health, Ningxia Medical University, Yinchuan 750004, Chi- na; 2. Health Service Station of Yihao Community, Medical Department of People＇s Hospital, Yinchuan 750001, China) |
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| Abstract: | Objective To compare the concentrations of 14 mineral elements in different blood glucose levels, and to analyse the relationship between serum mineral elements and the blood glucose. Methods A total of 3 391 persons from four villages in Ningxia were selected by the stratified cluster sampling method. A number of 1 612 blood samples were collected. Inductively coupled plasma emission spectrometry （ICP-AES） was used to determine the contents of 14 serum mineral elements in 1 493 subjects. Results The serum chromium in NFG（6. 35 ±2.75） μg/ml was significantly higher than that in DM （5.47 ±2.09） μg/ml and the serum strontium in IFG1 （0. 13 ±0. 04） was higher than that in NFG（0. 11 ±0.05 ） μg/ml. Serum copper in NFG （0. 99 ±2. 14） μg/ml was lower than IFG1 （ 1.00 ±2. 24 ） μg/ml, IFG2 （ 1.03 ± 2. 06） μg/ml and DM（ 1.07 ±2. 48）μg/ml in the groups and serum copper in DM was higher than IFG2. Serum gallium in DM group（0. 16 ±0.08） μg/ml was higher than the three groups of NFG （0. 12 ±0.08） μg/ml, IFGI（0. 13 ±0.08） μg/ml and IFG2 （0. 13 ±0. 08） μg/ml. Partial correlation analysis showed that serum copper（r =0. 083, P =0. 017） and gallium （r = 0. 081, P = 0. 019） were positively correlated with blood sugar. While serum chromium （r = -0. 074, P = 0. 032） was negatively correlated with blood sugar; While serum copper（r =0. 098,P =0. 005） and strontium（r =0. 087, P = 0. 012） indexes were positively correlated with insulin resistance. Logistic regression analysis showed that Cu （OR = 1. 511% ,95% CI：I. 072-2. 151 ） and Ca（ OR = 1. 618,95% CI： 1. 076-2. 432） were risk factors for abnormal blood sugar, when Ca reached the highest concentration, the risk of abnormal blood sugar showed highest. As a contrast, Sr （ OR = 0. 800,95% CI：0. 678-0. 944） was the protective factor of abnormal blood sugar. Conclusions The serum copper, gallium and chromium are closely related to blood sugar levels. Copper, strontium and calcium |
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| Keywords: | Blood glucose Minerals Elements |
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