Vitamin D supplementation,bone turnover,and inflammation in HIV-infected patients |
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Authors: | L Benguella A Arbault A Fillion M Blot C Piroth D Denimal L Duvillard P Ornetti P Chavanet J-F Maillefert L Piroth |
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Institution: | 1. Département d’infectiologie, CHU de Dijon, 21079 Dijon, France;2. Service de Rhumatologie, CHU de Dijon, 21079 Dijon, France;3. UMR U866, département de biochimie, université de Bourgogne, 21079 Dijon, France;4. Inserm U1093, université de Bourgogne, 21079 Dijon, France;5. Inserm CIC 1432, université de Bourgogne, 21079 Dijon, France |
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Abstract: | ObjectiveTo assess whether vitamin D supplementation could be associated with a modification of inflammatory markers and bone turnover in HIV-1-infected patients.Patients and methodsPatients who participated in an initial survey in 2010 and who were followed in the same department were included in a new study in 2012. Between 2010 and 2012, vitamin D supplementation was offered to patients presenting with hypovitaminosis D as per appropriate guidelines. Clinical examinations were performed, and fasting blood samples were taken for inflammation and bone marker evaluations.ResultsOf the 263 patients who participated in the 2010 study, 198 were included in the 2012 study. Hypovitaminosis D was observed in 47% (36/77) of participants supplemented as per appropriate guidelines, in 78% (75/97) of transiently or incompletely supplemented participants, and in 71% (17/24) of non-supplemented participants (mainly because vitamin D levels in 2010 were normal). No significant correlation between vitamin D supplementation and the 2-year inflammation outcome (IL-6 and hsCRP) or C-terminal telopeptide levels was observed. However, a decrease in IL6 levels over the 2 years significantly correlated with reaching a normal vitamin D level (OR = 0.89 per +1 pg/mL IL6 increase, 95% CI = 0.81–0.97, P = 0.015).ConclusionsVitamin D supplementation decreases the risk of hypovitaminosis D but does not decrease the risk of inflammation nor bone turnover, unless normal 25-OH vitamin D levels are reached. |
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Keywords: | HIV Antiretroviral therapy Vitamin D Hypovitaminosis D Inflammation VIH Traitement antirétroviral Vitamine D Hypovitaminose D Inflammation |
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