| Graves病患者血清中甲状腺刺激性抗体测定的实验研究 |
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| 引用本文： | 陈格,叶维新.Graves病患者血清中甲状腺刺激性抗体测定的实验研究[J].华中科技大学学报(医学版),1986(5). |
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| 作者姓名： | 陈格 叶维新 |
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| 作者单位： | 同济医科大学实验医学研究中心核医学研究室
(陈格)，同济医科大学实验医学研究中心核医学研究室(叶维新) |
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| 摘 要： | 利用一种新的放射配体-受体结合分析法,以~(125)I-SPA作为示踪配体,对165名Graves病(GD)患者血清中的甲状腺刺激性抗体(TSab)进行了检测:在GD初发组、治疗组、临床缓解组、复发组的阳性率分别为91％、32％、28％、90％。在12例甲状腺腺癌患者中检出2例阳性,而在50名正常对照者中均未检出TSab活性。作者认为:GD患者血清中存在TSab,其水平变化与临床疾病转归具有一定规律性,TSab检测对GD临床治疗监测、复发预测具有一定参考价值。
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| 关 键 词： | Graves病 甲状腺刺激性抗体 放射受体分析 金黄色葡萄球菌A蛋白 |
The Experimental Studies for Detection of Thyroid Stimulating Antibodies(TSab) in Sera of Patients with Graves' Disease |
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| Chen Ge,Ye Weixin Nuclear Medicine Research.The Experimental Studies for Detection of Thyroid Stimulating Antibodies(TSab) in Sera of Patients with Graves'''' Disease[J].Journal of Huazhong University of Science and Technology(Health Sciences),1986(5). |
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| Authors: | Chen Ge Ye Weixin Nuclear Medicine Research |
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| Abstract: | Using a new radio-receptor assay taken 125I-Staphylococcal protein A as tracing ligand,TSab levels have been detected in sera of 165 patients with Graves disease (GD).The TSab index (TSabI) was positive in 91% (n=67) of untreated GD,32% (n=28) of antithyroid drugs treated GD,28% (n=39) of GD in clinical remission and 90%(n=31) of relapsed GD.TSabI was negative in all normal controls and negative controls.These studies suggested:TSab existed in sera of most patients with GD,the changes cf TSab level were correlated with the clinical course of GD.The detection of TSab may be an useful parameter in monitoring clinical treatment of GD and predicting the GD recurrences. |
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| Keywords: | Graves disease thyroid stimulating antibody radio-receptor assay staphylococcal protein A |
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