| 骨水泥单体对新西兰白兔心肺功能的影响 |
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| 引用本文： | 周天宇,刘 锋. 骨水泥单体对新西兰白兔心肺功能的影响[J]. 南京医科大学学报(自然科学版), 2010, 0(5): 658-661 |
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| 作者姓名： | 周天宇 刘 锋 |
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| 作者单位： | 南京医科大学第一附属医院骨科; |
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| 基金项目： | 江苏省卫生厅面上项目(H200704);;江苏省第六批人才高峰项目 |
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| 摘 要： | 目的:通过动物实验探讨骨水泥单体(MMA)对新西兰白兔心肺功能的影响。方法:将28只新西兰白兔随机分为4组,每组7只。对照组静脉注射0.35ml生理盐水,其余各组静脉注射不同剂量的MMA,即:MAX(0.35ml)组、MID(0.10ml)组和MIN(0.02ml)组。静注后动态观察实验动物的血压心率变化;检测动脉血氧分压;观察实验动物心肺的病理改变。结果:MAX组7例均出现明显的血压下降、心律异常和氧分压下降,有6例死亡;MID组出现中等程度的血压下降和氧分压下降,无1例死亡;MIN组出现轻微的血压下降,心律异常和氧分压下降;对照组心率血压和血氧分压无明显变化。病理显示MAX组和MID组动物肺组织出血水肿,MAX组心脏标本可见心内膜下血栓。结论:MMA有心肌和肺毒性,具有剂量依赖性。MMA毒性可能是骨水泥植入综合征致病因素之一。
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| 关 键 词： | 骨水泥 聚甲基丙烯酸甲酯单体 心肌毒性 动脉氧分压 |
| 收稿时间： | 2009-12-01 |
The influence of bone cement monomer on New Zealand white rabbit's cardiopulmonary function |
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| ZHOU Tian-yu and LIU Feng. The influence of bone cement monomer on New Zealand white rabbit's cardiopulmonary function[J]. Acta Universitatis Medicinalis Nanjing, 2010, 0(5): 658-661 |
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| Authors: | ZHOU Tian-yu and LIU Feng |
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| Affiliation: | Department of Orthopaedics/a>;the First Affiliated Hospital of NJMU/a>;Nanjing 210029/a>;China |
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| Abstract: | Objective:To investigate the effect of methylmethacrylate monomer to New Zealand white rabbit's cardiopulmonary function by injecting methylmethacrylate monomer into vein.Methods:According to different injecting materials,New Zealand white rabbits were divided into two groups:Experimental group(methylmethacrylate monomer) and control group(physiological saline).According to different doses,experimental group were divided into three sub groups:MAX group(0.35 ml);MID group(0.10 ml);MIN group(0.02 ml).The fluc... |
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| Keywords: | bone cement methylmethacrylate monomer cardiac muscle toxicity arterial partial pressure of oxygen |
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