| 视网膜母细胞瘤组织发生的探讨 |
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| 引用本文： | 贾平凡,王新允,郑海燕. 视网膜母细胞瘤组织发生的探讨[J]. 天津医药, 1997, 0(5) |
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| 作者姓名： | 贾平凡 王新允 郑海燕 |
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| 作者单位： | 天津市第一中心医院，天津医科大学病理教研室，天津医科大学病理教研室 300192 |
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| 摘 要： | 应用免疫组织化学方法探讨视网膜母细胞瘤的组织来源。结果显示;神经胶质细胞标记物GFAP(12/25)、神经元标记物NSE(18/25)、S-100蛋白(10/25)瘤细胞呈不同程度的阳性反应。Vimentin瘤细胞全部呈阴性反应。结果提示:视网膜母细胞瘤来源于神经外胚层上皮,向神经元和光感受器方向分化。神经胶质细胞可能是反应性增生,但也不排除向神经胶质细胞方向分化的可能性。
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| 关 键 词： | 视网膜母细胞瘤 免疫组织化学 组织发生 |
Evaluation of Histogenesis of Retinoblastoma |
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| Jia Pingfan,Wang Xinyun,Zheng Haiyan. Evaluation of Histogenesis of Retinoblastoma[J]. Tianjin Medical Journal, 1997, 0(5) |
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| Authors: | Jia Pingfan Wang Xinyun Zheng Haiyan |
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| Affiliation: | Jia Pingfan,Wang Xinyun,Zheng Haiyan Department of Ophthalmology,Tianjin First Central Hospital 300192 |
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| Abstract: | The results of immunohistochemical study and the histogenesis of retinoblastoma were discussed. Immunohistochemical studies revealed that 12/25 cases were positive for GFAP, 18/25 cases were positive for NSE, 10/25 cases were positive for protein S-100,and all cases were negative for vimentin. The results suggested that retinoblastoma originated from the retinoblast with potential of differentiation into photoreceptors and neurons. The glial components pertained to reactive gliosis, however, the rare possibility of differentiation into glial cell could not be ruled out. |
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| Keywords: | retinoblastoma immunohistochemistry histogenesis |
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