Experimental Study of the Effects of Permafrost Microorganisms on the Morphofunctional Activity of the Immune System |
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| Authors: | L. F. Kalenova U. G. Suhovey A. V. Broushkov V. P. Melnikov T. A. Fisher I. M. Besedin M. A. Novikova J. A. Efimova A. M. Subbotin |
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| Affiliation: | (1) Institute of Physicochemical & Biological Problems in Soil Science, Russian Academy of Sciences, Pushchino, Russia; |
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| Abstract: | The immunobiological potential of a new microorganism species isolated from permafrost specimens (PMO strain 3 M) collected from the Mammoth Mountain in Yakutia was studied in laboratory mice. PMO injected intraperitoneally in doses of 2500 to 50 × 106 microbial bodies caused characteristic dose-dependent effects on the structure and functions of the immune system (thymus and spleen indexes, functional activity of splenic macrophages, cellular and humoral immunity). Doses of PMO stimulating functional activities of both cellular and humoral immunity were detected. |
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