Methylglyoxal impairs insulin signalling and insulin action on glucose-induced insulin secretion in the pancreatic beta cell line INS-1E |
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| Authors: | Fiory F Lombardi A Miele C Giudicelli J Beguinot F Van Obberghen E |
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| Affiliation: | (1) Dipartimento di Biologia e Patologia Cellulare e Molecolare and Istituto di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche, Universit? degli Studi di Napoli Federico II, Naples, Italy;(2) Inserm U907, IFR50, Facult? de M?decine, Universit? de Nice Sophia Antipolis, 28 Avenue de Valombrose, 06107 Nice Cedex 2, France;(3) Laboratoire de Biochimie, H?pital Pasteur, CHU de Nice, Nice, France; |
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| Abstract: | Aims/hypothesis Chronic hyperglycaemia aggravates insulin resistance, at least in part, by increasing the formation of advanced glycation end-products (AGEs). Methylglyoxal (MGO) is the most reactive AGE precursor and its abnormal accumulation participates in damage in various tissues and organs. Here we investigated the ability of MGO to interfere with insulin signalling and to affect beta cell functions in the INS-1E beta cell line. |
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