Pure word deafness due to left subcortical lesion: Neurophysiological studies of two patients |
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| Institution: | 1. Department of Internal Medicine, Kakeyu Hospital Rehabilitation Center, Japan;2. Department of Neurology, Okaya City Hospital, Okaya 394-8512, Nagano, Japan;1. The Fourth People’s Hospital of Jinan City, Jinan, Shandong, China;2. Shangdong University of Traditional Chinese Medicine, Jinan 250031, Shandong, China;1. Manchester Centre for Audiology and Deafness, University of Manchester, Manchester Academic Health Science Centre, Manchester, M13 9PL, United Kingdom;2. Department of Psychology, Lancaster University, Lancaster, LA1 4YF, United Kingdom;3. Ear Institute, University College London, London, WC1X 8EE, United Kingdom;4. Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, M13 9WK, United Kingdom;1. Department of Otolaryngology – HNS, Program in Neuroscience and Mental Health, The Hospital for Sick Children, 555 University Ave, Toronto, Ontario, Canada M5G 1X8;2. Department of Otolaryngology – Head and Neck Surgery, University of Toronto, 190 Elizabeth Street, Toronto, Ontario, Canada MG5 2N2;1. Key Laboratory of Targeted Intervention of Cardiovascular Disease and Collaborative Innovation Center for Cardiovascular Translational Medicine, Department of Pathophysiology, Nanjing Medical University, Nanjing, China;2. Institute of Biomedical Research, Liaocheng University, Liaocheng, China;3. The Laboratory Center for Basic Medical Sciences, Nanjing Medical University, Nanjing, China |
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| Abstract: | ObjectiveThis study investigated the auditory processing in two patients with pure word deafness (PWD) using neurophysiological experimental methods.MethodsWe recorded the auditory brainstem response (ABR), the middle latency auditory-evoked response (MLR) and the auditory-evoked event-related potentials (ERPs) in two patients with PWD after subcortical hemorrhage in the left temporal lobe.ResultsBoth patients showed normal response in ABR and abnormality in MLR. The latency of P300 evoked by right-ear stimulation was 51 ms longer in one patient and 26 ms longer in the other patient than that evoked by left-ear stimulation.ConclusionsOur results suggested that the prolongation of P300 latency could be caused by the deterioration of auditory stimulus processing and supported the hypothesis that the defect in auditory temporal resolution was an important factor in the development of PWD.SignificanceThis study demonstrated that recordings of ERP with auditory-evoked response such as ABR and MLR are useful to elucidate the deterioration of auditory stimulus processing in patients with PWD. |
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