| 奥美拉唑对65例消化性溃疡的疗效 |
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| 引用本文： | 张贤康,陈士葆,李桂生,张兴荣,杨秀疆.奥美拉唑对65例消化性溃疡的疗效[J].中国新药与临床杂志,1992(5). |
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| 作者姓名： | 张贤康 陈士葆 李桂生 张兴荣 杨秀疆 |
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| 作者单位： | 第二军医大学附属长征医院消化内科 上海200003
(张贤康，陈士葆，李桂生，张兴荣)，第二军医大学附属长征医院消化内科 上海200003(杨秀疆) |
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| 摘 要： | 奥美拉唑20mg,qd,口服治疗活动性胃或十二指肠溃疡65例(Ome组:男59,女6;年龄41±13a)。雷尼替丁0.15g,bid,口服,治疗42例(Ran组:男39,女3;年龄42±11a)作比较。疗程4-6wk。服药后疼痛消除:Ome组90％在3d内,Ran组92％需7-8d。十二指肠溃疡愈合率:Ome组(43例)4wk达100％,Ran组(30例)70％(P<0.01),胃溃疡愈合率:Ome组(22例)6wk为95％,Ran组(12例)67％(P<0.01)
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| 关 键 词： | 奥美拉唑/治疗应用 雷尼替丁/治疗应用 消化性溃疡/药物疗法 |
Omeprazole for peptic ulcer in 65 patients |
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| ZHANG Xian-Kang,CHEN Shi-Bao,LI Gui-Sheng,ZHANG Xing-Rong,YANG Xiu-Jiang.Omeprazole for peptic ulcer in 65 patients[J].Chinese Journal of New Drugs and Clinical Remedies,1992(5). |
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| Authors: | ZHANG Xian-Kang CHEN Shi-Bao LI Gui-Sheng ZHANG Xing-Rong YANG Xiu-Jiang |
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| Abstract: | Sixty-five patients with active peptic ulcer (group Ome) were treated with omeprazole 20mg qd, po, while 42 patients with the same suffering (group Ran) were given ranitidine 0.15g bid po as control four to six wk as a course. Pain relieved within 3 d in 90% of the patients in group Ome and within 7-8 d in 92% of the patients in group Ran. The healing rate of duodenal ulcer (DU) at the end of wk 4 (4th wk) was 100% in the group Ome and 70% in the group Ran. The healing rate of gastric ulcer (GU) at wk 6 was 95% in the group Ome, and 67% in the group Ran. The differences between the healing rates of group Ome and group Ran in DU and GU were all statistical significant (P<0.01). The healing rate of duodenal ulcer was not affected by the size of the ulcer area. No adverse effects were found in this study. |
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| Keywords: | omeprazole/therapeutic use ranitidine/therapeutic use peptic ulcer/drug therapy |
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