| 缬沙坦对大鼠心室肌细胞L-型钙通道电流的影响 |
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| 引用本文： | 王志权,马业新,刘念,周强.缬沙坦对大鼠心室肌细胞L-型钙通道电流的影响[J].临床军医杂志,2007,35(3):330-333. |
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| 作者姓名： | 王志权 马业新 刘念 周强 |
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| 作者单位： | 1. 解放军第161医院,心内科
2. 同济医科大学附属同济医院,心内科,湖北,武汉,430010 |
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| 摘 要： | 目的研究AT1受体拮抗剂缬沙坦对正常大鼠心室肌细胞L-钙电流(Ica-L)的影响。方法采用全细胞膜片钳技术,观察0.4μmol/L的缬沙坦引起单个大鼠心室肌细胞L型钙通道电流变化。结果0.4μmol/L缬沙坦使正常大鼠心室肌细胞L型钙电流峰值明显降低(P<0.01),I-V曲线上移,但不改变其激活电位、峰值电位和反转电位。不影响通道稳态激活曲线,使稳态失活曲线左移。结论0.4μmol/L缬沙坦可直接阻断大鼠心室肌细胞L型钙通道,改变心室肌细胞的电生理特性,可能是其抗心律失常的机制之一。
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| 关 键 词： | 缬沙坦 心室肌 L型钙电流 膜片钳 |
| 文章编号： | 1671-3826（2007）03-0330-04 |
| 收稿时间： | 2007-03-30 |
| 修稿时间： | 2007-03-30 |
Effects of Valsartan on L-type Calcium Channel Current in SD Rat Ventricular Myocytes |
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| Wang Zhi-quan,Ma Ye-xin,Liu Nian,Zhou Qiang.Effects of Valsartan on L-type Calcium Channel Current in SD Rat Ventricular Myocytes[J].Clinical Journal of Medical Officer,2007,35(3):330-333. |
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| Authors: | Wang Zhi-quan Ma Ye-xin Liu Nian Zhou Qiang |
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| Institution: | 1. Department of Cardiology, PLA No. 161 Hospital, Wuhan 430010, China; 2. Department of Cardiology, Tongji Hospital of Tongji Medical University, Wuhan 430010, China |
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| Abstract: | Objective To study the effects of valsartan on L-type calcium channel current in SD rat ventricular myocytes. Methods Whole-cell patch clamp technique was used to study the effects of valsartan (0.4 μmol/L) on L-type calcium current in single SD rat ventricular myocytes. Results 0.4 μmol/L valsartan reduced significantly the peak current of ICa,L (P<0.01) and the I-V curve of ICa,L was shifted upwards, but the activation voltage, the maximal activation voltage and the reversal potential of ICa,L were not altered by valsartan. Valsartan had no significant effect on steady-state activation curve, but steady-state deactivation curve of ICa,L were shifted leftwards. Conclusion Valsartan (0.4 μmol/L) inhibits directly ICa,L in SD rat ventricular myocytes and alters the electrophysiology of ventricular myocytes. This may be one of its antiarrhythmic mechanisms. |
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| Keywords: | valsartan ventricular myocyte L-type calcium current patch clamp |
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