经瞳孔温热疗法作用后兔实验性脉络膜新生血管组织学变化

目的观察经瞳孔温热疗法(TTT)治疗实验性兔脉络膜新生血管(CNV)的组织学改变,并探讨其机制。方法用多波长氪离子激光对5只有色家兔(10只眼)进行眼底光凝,诱导出CNV,每周行眼底荧光血管造影检查,3周后采用波长810nm半导体激光进行TTT治疗,术后随访2~11周,不同时间点处死家兔,行光镜检查。结果光凝后第3周部分光凝斑出现荧光素渗漏。TTT治疗后1~8周光镜观察,可见病灶局限,视网膜与脉络膜粘连,成纤维细胞增生。结论TTT治疗后,加速了CNV损伤的瘢痕修复。

Histologic Examination of Experimental Choroidal Neovascularization after Transpupillary Thermotherapy in Pigmented Rabbits

Objective To study the different time effects of transpupillary thermotherapy (TTT) on experimental choroidal neovascularization ( CNV ) in the pigmented rabbits, and to investigate the probable mechanism. Methods TTT was performed in 5 rabbits(10 eyes) with experimental CNV induced by high-intensity red krypton laser photocoagulation. TTT was performed using IRIS diode laser 810 nm after induced 3 weeks. Follow-up studies, including fundus photography and FFA, were performed weekly. Tissues were examined with light microscopy at different time between 2 and 11 weeks. Results Some photocoagulation spots showed angiographic leakage at 3 weeks. Lesions were limited with retina and choroid adherence, fibrocyte proliferation evaluated by light microscope after TTT treatment. Conclusions Compared with the lesions without TTT treatment, TTT treatment can accelerate the lesions scar repair.