胰蛋白酶原-2在AP诊断中的作用及与淀粉酶和脂肪酶的对比实验

目的:探讨尿胰蛋白酶原-2在急诊急性胰腺炎(AP)诊断中的应用及与淀粉酶、脂肪酶的比较。方法:尿胰蛋白酶原-2采用免疫层析法,淀粉酶采用PNP-G7法,脂肪酶采用比浊法。对急诊AP病人59例在入院时进行上述三个项目的测定。对照组为诊断为非胰腺炎的病人。结果:AP患者中有58例胰蛋白酶原-2为阳性,诊断敏感性、特异性、阳性预期值和阴性预期值分别达到98.3%、92%、93.5%和97.9%,明显高于淀粉酶和脂肪酶,AP组和对照组差别有统计学意义。结论:胰蛋白酶原-2具有简便、快速、准确的优点,是急诊诊断AP的一个良好的指标。

The Role of Urinary Trypsinogen-2 in Diagnosis of Acute Pancreatitis and Comparing with Amylase and Lipase

Objective To inverstigate the role of urinary trypsinogen-2 in diagnosis of acute pancreatitis and comparing with amylase and lipase. Methods To measure urinary trypsinogen-2 with immunochromatography, AMY with method by PNP-G7 ,LIP with immunoprecipitation. 48 patients with AP were measured three items when admitted to hospital. The control group contains patients without AP. Results Urinary trypsinogen-2 of 58 patients with AP were positive. The sensitivity, specificity, positive predicting rate and negative predicting rate were 98.3%, 92 %, 93.5 %, 97. 9%. They are much higher than that of AMY and LIP. The difference between the AP group and control group has sta tistics significance. Conclusion Urinary trypsinogen-2 has simple, quick and accurate advantage. It is a better maker for diagnosis of AP.