Fn14在食管鳞癌中的表达及其临床意义

目的 探讨成纤维细胞生长因子诱导分子14（Fn14）在食管鳞癌组织中的表达及其与食管鳞癌患者临床病理特征及预后的关系。方法 采用免疫组织化学法检测118例行根治切除手术的食管癌患者肿瘤组织及配对正常食管鳞状上皮黏膜组织中Fn14蛋白的表达情况。分析Fn14蛋白表达与食管鳞癌患者临床病理特征的关系。采用Kaplan-Meier法进行生存分析，Cox风险回归模型评估影响食管鳞癌患者预后的因素。结果 Fn14在食管鳞癌组织中的阳性表达率为51.7%（61/118），高于正常黏膜组织的4.2%（5/118），差异有统计学意义（P＜0.001）。食管鳞癌患者Fn14蛋白表达与淋巴结转移、TNM分期有关（P＜0.05）。Fn14蛋白阳性表达者的中位生存期（OS）为23个月（95%CI：17~29个月），而Fn14蛋白阴性表达患者的中位OS为54个月（95%CI：50~58个月），差异有统计学意义 （P＜0.001）。Cox多因素回归分析显示，除T分期、N分期外，Fn14蛋白表达亦是食管鳞癌患者预后的独立预测因子（HR=1.51， 95%CI： 1.02~2.24；P=0.022）。结论 Fn14蛋白表达具有重要的临床价值，可作为判断食管鳞癌患者预后的标志物。

Expression of Fn14 in esophageal squamous cell carcinoma and its clinical significance

Objective To investigate the expression of fibroblast growth factor-inducible 14（Fn14）in esophageal carcinoma and its relationship with clinical data and prognosis of patients with esophageal squamous cell carcinoma（ESCC）. Methods In this study， Fn14 expression in tumor tissues was assessed using immunohistochemical（IHC）methods in 118 patients with resected ESCC. The association of Fn14 expression with clinicopathological parameters were also evaluated. Kaplan-Meier survival analysis and Cox proportional hazards models were used to estimate the effect of Fn14 expression on survival. Results It showed that Fn14 was expressed in 51.7% （61/118） and 4.2% （5/118） of cancer lesions and corresponding adjacent non-cancerous tissue， respectively （P＜0.001）. Fn14 expression was significantly correlated with lymphatic metastasis and TNM stage（P＜0.001）. The median overall survival of Fn14 positive expression patients and negative expression patients were 23 months（95%CI：17-29 months） and 54 months（95%CI：50-58 months） with statistical significance （P＜0.001）. Multivariate analysis indicated that in addition to the T and N stage， Fn14 expression may also be an independent prognostic factor in ESCC （HR=1.51， 95%CI：1.02-2.24， P=0.022）. Conclusion Fn14 expression is of clinical significance and can serve as a prognostic biomarker in ESCC.