Latexin在食管鳞癌组织中的表达及其临床价值

目的 探讨Latexin（LXN）在食管鳞癌组织中的表达情况及临床价值。方法 采用组织芯片和免疫组织化学技术检测183例食管鳞癌组织中的LXN蛋白表达，并分析其表达情况与临床病理参数（肿瘤大小、T分期、N分期、分化程度和TNM分期）及预后间的关系。结果LXN在癌旁食管鳞状上皮中呈微弱表达，阳性表达率为100.0%，而在食管鳞癌组织中呈淡黄色或不表达，其阳性表达率为48.6%（89/183），低于癌旁组织（P＜0.05）；LXN阳性表达与肿瘤大小、T分期、N分期、组织分化及TNM分期有关。单因素生存分析表明LXN阳性表达者的中位总生存期长于LXN阴性表达者（P=0.001）。结论LXN在食管鳞癌中表达下调，且与临床病理参数有关，在一定程度上反映了食管癌的不良预后。

Expression of Latexin and its clinicopathological significance in esophageal squamous cell carcinoma

Objective To investigate the clinical significance of Latexin（LXN） in esophageal squamous cell carcinoma（ESCC）. Methods In this study， 183 cases of ESCC tissues and para-carcinoma tissues were evaluated for LXN expression by tissue microarray and immunohistochemistry. The relationship between the expression of LXN and clinical parameters（tumor size， T staging, N stagings, differentiation and TNM staging） and prognosis were analyzed. Results The positive rate of LXN expression was 48.6% in ESCC tissues， lower than 100.0% in para-carcinoma tissues. A significant correlation was observed between the expression of LXN and tumor size， T staging, N staging， tumor differentiation and TNM staging. Patients with LXN positive expression had longer overall survival than those without LXN expression. Conclusion LXN was down-regulated with the development and progression of ESCC and loss of LXN expression is associated with the poor prognosis of ESCC.