口腔细菌生物膜对抗菌剂的敏感性

许多研究证实生物膜中的细菌对抗菌剂的敏感性比其处于浮游状态时要低得多 ,而口腔细菌却常以生物膜方式致病 ,对许多抗菌剂具有很强的抵抗力 ,这就造成实验室的药敏结果用于临床效果不佳。因此详细了解处于生物膜状态的口腔细菌对抗菌剂的敏感性 ,对于临床上治疗和预防许多口腔疾病具有重要意义

The susceptibility of oral bacterial biofilms to antimicrobial agents

It has been well established that the susceptibility of bacteria to antimicrobial agents is much lower when they comprise a biofilm than they are in an aqueous suspension.Oral bacteria are often pathogenesis through organising biofilms, so oral bacteria in biofilms have also strong resistance to many kinds of antimicrobial agents.But we usually determine the minimum inhibitory concentration (MIC) of antimicrobial agents to a kind of bacterial species in planktonic state not in biofilm, this will lead to the MIC results unsuitable for clinical treatment.The susceptibility of oral bacteria in biofilms to antimicrobial agents should be studied in detail necessarily.It is very important to clinical treatment and prophylaxis of many oral diseases.