CYP4A11基因单核苷酸多态性与高血压的相关性研究

目的:研究CYP4A11基因单核苷酸多态性与高血压的相关性。方法:收集304例日本高血压患者(高血压组)和207例年龄匹配、血压正常的日本人(对照组),选择CYP4A11基因的3个单核苷酸多态性(SNPs,rs2269231,rs9333025,rs1126742),应用TaqMan SNP基因分型的方法进行基因分型,分析并比较不同性别高血压组和对照组3个SNPs基因型频率和等位基因频率的分布,并应用Logistic回归分析方法分析高血压主要危险因素对结果的影响,分析CYP4A11基因与高血压的相关性。结果:全体,高血压组和对照组rs1126742的基因型分布差异有统计学意义(P=0.005);对于全体、男性、女性,高血压组和对照组的rs1126742的隐性模型分布(CCversus CT TT)存在差异(P分别为0.007、0.043、0.045);Logistic回归分析显示,对于全体和男性,rs1126742的CT TT基因型更常见于高血压患者(P分别为0.015、0.048)。结论:CYP4A11基因的rs1126742可作为日本男性高血压标志,其CT TT基因型与日本男性高血压有关。

Association between the SNPs of human CYP4A11 gene and essential hypertension

Objective:The aim of the present study was to assess the association between the human CYP4A11 gene and essential hypertension (EH), using a case control study that included a separate analysis of the gender groups. Methods: There were 304 EH patients and 207 age-matched controls genotyped for 3 SNPs of the human CYP4A11 gene (rs2269231, rs1126742, rs9333025). The data were assessed for 3 separate groups: the total subjects, men and women. Results: For the total, the genotypic distribution of rs1126742 differed significantly between the two groups (P=0.005). For the total, and the men and women groups, the recessive model (CC versus TC TT) of rs1126742 differed significantly between the two groups (P=0.007, 0.043, 0.045, respectively). Logistic regression analysis showed that the TC TT genotype was significantly higher in EH patients than in controls for the total subjects and the men (P=0.022, 0.043, respectively). Conclusions: The present results indicate that rs1126742 of CYP4A11 gene can be a marker of EH in Japanese men. The TC TT genotype of rs1126742 is associated with EH in Japanese men.