正交试验法筛选氢溴酸右美沙芬颗粒的制粒工艺

目的:通过改变黏合剂的浓度、用量和搅拌时间等制粒工艺,进一步优化湿法制粒参数,提高制粒收率.方法:通过糖浆浓度(A,50%、60%、65%)、糖浆加入量(B,200、250、300 g)、搅拌时间(C,6、8、10 min)等湿法制粒工艺参数为研究因素水平,采用正交试验法以制粒收率为考察指标,优化筛选氢溴酸右美沙芬颗粒...

Granulating process of dextromethorphan hydrobromide particles with orthogonal experiment method

Objective：To improve the granulating process of making dextromethorphan hydrobromide particles for optimized wet granulation parameters and higher granulation yield by changing concentration of binding agent,dosage and mixing time.Methods：Different syrup concentration（A,50%,60%,65%）,syrup dosage（B,200,250,300g）,mixing time（C,6,8,10min） and other parameters were applied for granulating process of dextromethorphan hydrobromide particles with orthogonal experiment method.Results：The result showed A_3B_3C_3 was the optimum parameters for granulating process of dextromethorphan hydrobromide particles with orthogonal method,specifically,65% syrup 300g,10 min stirring for wet granulation can increase the yield.Conclusions：The wet granulation process that takes 65% syrup 300 g as binding agents and stirring time of 10 min can increase the granulation yield of dextromethorphan hydrobromide particles and it is feasible.