| 多药耐药基因1与肝癌 |
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| 引用本文： | 王永存,余忠华,李芸.多药耐药基因1与肝癌[J].海南医学,2011,22(5):133-136. |
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| 作者姓名： | 王永存 余忠华 李芸 |
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| 作者单位： | 广东医学院附属医院肿瘤中心,广东湛江,524001 |
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| 摘 要： | 目前认为肝癌化疗失败的主要原因与多药耐药有关,而多药耐药基因1(Multi-drug resistance 1gene,mdr1)编码的P-gP蛋白(Permeability-glycoprotein)被认为可能是参与肿瘤多药耐药的主要因素之一.目前的研究发现,mdr1参与肝癌的多药耐药可能与多种机制有关,而且mdr1...
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| 关 键 词： | 多药耐药基因1 肝癌 多药耐药 |
Relationship between multi-drug resistance 1 gene and hepatocellular carcinoma |
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| WANG Yong-cun,YU Zhong-hua,LI Yun.Relationship between multi-drug resistance 1 gene and hepatocellular carcinoma[J].Hainan Medical Journal,2011,22(5):133-136. |
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| Authors: | WANG Yong-cun YU Zhong-hua LI Yun |
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| Institution: | .Tumor Treatment Center,the Affiliated Hospital to Guangdong Medical College,Zhanjiang 524001,Guangdong,CHINA |
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| Abstract: | In current knowledge,the main reason of the failure in the chemotherapy of hepatocellular carcinoma is due to multi-drug resistance,and the permeability glycoprotein(P-gp) coded by Multi-drug resistance 1 gene(mdr1) is supposed to be one of the main factors which lead to multi-drug resistance of tumors.Recent researches discover the relationship between mdr1 and multi-drug resistance of hepatocellular carcinoma maybe via several mechanisms,mdr1 also affects angiogenesis and apoptosis of hepatocellular carcinoma.It is becoming the important strategies in reversing multi-drug resistance of hepatocellular carcinoma to use physical ways,drugs,molecular biology technology and cell factors to inhibit/interfere the expression of mdr1 and the function of P-gp. |
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| Keywords: | Multi-drug resistance 1 gene Hepatocellular carcinoma Multi-drug resistance |
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