| 血管瘤发病机制的研究进展 |
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| 引用本文： | 王延安,蒋欣泉,郑家伟,张志愿.血管瘤发病机制的研究进展[J].中国口腔颌面外科杂志,2005,3(1):76-79. |
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| 作者姓名： | 王延安 蒋欣泉 郑家伟 张志愿 |
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| 作者单位： | 上海第二医科大学,附属第九人民医院,口腔医学院,口腔颌面外科,上海,200011 |
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| 基金项目： | 国家自然科学基金(30371546) |
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| 摘 要： | 幼年性血管瘤(infantial hemangiomas)是婴幼儿最常见的良性肿瘤，发病率高，危害性大。由于其确切病因不明，目前缺乏有效的治疗手段。随着分子生物学的发展，人们对血管瘤发病机制的研究取得了一定的进展，许多新的血管瘤分子标志相继被发现。可溶性细胞因子、基因突变、内皮祖细胞、细胞凋亡等在血管瘤发病中的作用已被众多学者所证实。本文对血管瘤发病机制的研究进展进行综述。
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| 关 键 词： | 幼年性血管瘤 发病机制 细胞因子 基因突变 内皮祖细胞 细胞凋亡 |
| 文章编号： | 1672-3244(2005)01-0076-04 |
| 修稿时间： | 2004年7月12日 |
Research advances of the pathogenesis of hemangiomas |
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| WANG Yan-an,JIANG Xin-quan,ZHENG Jia-wei,ZHANG Zhi-yuan.Research advances of the pathogenesis of hemangiomas[J].China Journal of Oral and Maxillofacial Surgery,2005,3(1):76-79. |
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| Authors: | WANG Yan-an JIANG Xin-quan ZHENG Jia-wei ZHANG Zhi-yuan |
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| Abstract: | Infantial hemangiomas are the most common tumors of infancies,with a high incidence of 1% to 2%. Approximately, 10% of hemangiomas are problematic,endangering or even life-threatening . The cellular and molecular mechanisms responsible for the pathogenesis of hemangiomas are mostly unknown. With the development of molecular biology,great advances have been made in the research of the pathogenesis of hemangiomas, and many new molecular markers were identified. Soluble cytokines, gene mutations,endothelial progenitor cells and apoptosis may play important roles in the hemangiogenesis. In this paper,we attempt to review the research advances of the pathogenesis of infantial hemangiomas. |
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| Keywords: | Infantial hemangiomas Pathogenesis Cytokine Gene mutations Endothelial progenitor cells Apoptosis |
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