| 凋亡抑制因子survivin在肝细胞肝癌的表达及临床意义 |
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| 引用本文： | 廖维甲,覃理灵,梅铭惠.凋亡抑制因子survivin在肝细胞肝癌的表达及临床意义[J].现代肿瘤医学,2007,15(8):1137-1138. |
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| 作者姓名： | 廖维甲 覃理灵 梅铭惠 |
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| 作者单位： | 桂林医学院附属医院肝胆外科研究室,广西,桂林,541001 |
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| 摘 要： | 目的:探讨survivin mRNA在肝细胞肝癌(HCC)及癌旁组织的表达及意义。方法:用逆转录聚合酶链反应测定32例HCC癌组织及癌旁组织中survivin mRNA的表达。结果:Survivin mRNA在HCC组织中高度表达,阳性率为65.6%,癌旁组织中未见表达,Survivin mRNA的表达与HCC门静脉癌栓发生密切相关(P<0.05),而与其它指标无明显差异。结论:Survivin mRNA高表达可以作为判断HCC侵袭性和进展的一个潜在重要指标。
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| 关 键 词： | 癌 肝细胞 |
| 文章编号： | 1672-4992-（2007）08-1137-02 |
| 修稿时间： | 2006-11-07 |
The expression of survivin and its clinical significance in hepatocellular carcinoma |
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| LIAO Wei-jia,QIN Li-ling,MEI Ming-hui.The expression of survivin and its clinical significance in hepatocellular carcinoma[J].Journal of Modern Oncology,2007,15(8):1137-1138. |
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| Authors: | LIAO Wei-jia QIN Li-ling MEI Ming-hui |
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| Institution: | Affiliated Hospital of Guilin Medical College, Guilin 541001, China. |
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| Abstract: | Objective:To investigate the expressions and significance of survivin mRNA in hepatocellular carcinoma(HCC) tissues.Methods:RT-PCR was used to detect the expression of survivin mRNA in samples of HCC tissue from 32 patients.Results:The expression of survivin mRNA in the HCC tissues was significantly higher,expression rate was 65.6%,no expression was detectable in paratumor tissue.There was significant correlation between the expression of survivin mRNA in HCC and the tumor thrombus in portal vein(P<0.05).Conclusion:The survivin mRNA high expression is of potential value in judging invasion and progression of HCC. |
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| Keywords: | Survivin |
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