白细胞介素-6在绝经后干燥综合征中的意义

目的：探讨白细胞介素-6（IL-6）在绝经后女性原发性干燥综合征（primary Sjoegren＇s syndrome，pSS）中的作用。方法：应用酶联免疫吸附试验（ELISA）测定21例绝经后pSS患者（患者组）和21例绝经后健康女性（对照组）血清及唾液中IL-6水平，并依本院常规方法检测患者血清IgG、IgA、IgM和血沉（ESR）。结果：患者组血清及唾液IL-6水平高于对照组（P〈0．01）。患者组血清及唾液IL-6水平与血清IgG、ESR水平呈直线正相关（r分别为0．699，0．757和0．546，0．544，t分别为4．261，5．050和2．841，2．826，P〈0．01或P〈0．05），与血清IgA、IgM水平无直线关系（r分别为0．392，0．412和0．393，0．291，t分别为1．857，1．971和1．863，1．326，P〉0．05）。患者组血清IL-6与唾液IL-6水平呈直线正相关（r=0．649，t=3．718，P〈0．01）。结论：IL-6可能主要通过诱导IgG的合成和分泌参与pSS的发病及进展，唾液IL-6水平可反映血清IL-6水平，用于评估病情活动性。

Study on IL-6 in Postmenopausal Women with Sj(o)gren's Syndrome

Objective: To investigate the role of interleukin-6 (IL-6) in the pathogenesis of primary Sjogren's syndrome (pSS). Methods: Serum and saliva specimen of twenty-one postmenopausal patients with pSS(the pSS group) and twenty-one postmenopausal healthy women(the control group) were collected. Enzyme linked immunosorbent assay (ELISA) were used to determine levels of IL-6 then IgG, IgA, IgM and ESR were measured by routine methods in our hospital. Results: The serum and saliva level of IL-6 in pSS patients were higher than that in the control group (P < 0.01). The serum and saliva level of IL-6 in the pSS group had linear positive correlation with IgG and ESR in serum (r=0.699, 0.757 and 0.546,0.544 t=4.261, 5.050 and 2.841,and 2.826 respectively, P < 0.01 or P < 0.05, but had no linear correlation with IgA and IgM in serum (r=0.392, 0.412 and 0.393, 0.291, t=1.857, 1.971 and 1.863,1.326 respectively, P > 0.05). The serum and saliva level of IL-6 in pSS patients had linear (r=0.649, t=3.718, P < 0.01). Conclusion: IL-6 is an important factor on the pathogenesis and perpetuation of pSS by inducing IgG synthesis and secretion. The IL-6 level in saliva which may be a indicator of that in serum can be used to evaluate the activity of pSS.