| 中国人非小细胞肺癌EGFR基因突变的研究 |
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| 引用本文： | 姜斌,朱冠山,刘峰,龚圣济,姚宝娣,钟镭,朱忠政,曾骥孟. 中国人非小细胞肺癌EGFR基因突变的研究[J]. 上海交通大学学报(医学版), 2005, 25(11): 1148-1150 |
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| 作者姓名： | 姜斌 朱冠山 刘峰 龚圣济 姚宝娣 钟镭 朱忠政 曾骥孟 |
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| 作者单位： | [1]上海第二医科大学宝钢医院肿瘤科,上海201900 [2]上海基康生物技术有限公司,上海201900 [3]第二军医大学长征医院胸心外科,上海201900 [4]解放军第113医院病理科,上海201900 |
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| 摘 要： | 目的研究中国人非小细胞肺癌表皮生长因子受体(EGFR)基因突变的情况.方法采用PCR扩增和基因测序,检测101例非小细胞肺癌(NSCLCs)EGFR外显子18、19和21的突变情况,并与国外报道的数据进行比较,同时分析其突变与临床特征的关系.结果共检测26例EGFR突变(25.7%),显著高于西方国家报道的数字,其中以腺癌、非吸烟者和女性突变率较高.结论中国人NSCLCs的EGFR突变率高于西方人种,更适宜靶向药物的治疗.
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| 关 键 词： | 表皮生长因子受体 非小细胞肺癌 基因突变 |
| 文章编号： | 0258-5898(2005)11-1148-03 |
| 修稿时间： | 2005-08-29 |
Mutational Analysis of EGFR in Chinese Patients with NSCLCs |
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| JIANG Bin,ZHU Guan-shan,LIU Feng,GONG Sheng-ji,YAO Bao-di,ZHONG Lei,ZHU Zhong-zheng,Eric TZENG. Mutational Analysis of EGFR in Chinese Patients with NSCLCs[J]. Journal of Shanghai Jiaotong University:Medical Science, 2005, 25(11): 1148-1150 |
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| Authors: | JIANG Bin ZHU Guan-shan LIU Feng GONG Sheng-ji YAO Bao-di ZHONG Lei ZHU Zhong-zheng Eric TZENG |
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| Abstract: | Objective To investigate gene mutations of the epidermal growth factor receptor(EGFR) in Chinese non-small cell lung cancers(NSCLCs). Methods Mutations of exons 18,19 and 21 of the EGFR in 101 NSCLCs were detected by PCR-amplifying and gene sequencing,and the relationship between mutations and clinical characters of NSCLCs were analyzed. Results Overall,we detected 26 EGFR mutations(25.7%),and found mutation frequencies in adenocarcinomas,nonsmoker and female were high. Conclusion Our data suggest that mutation frequency of EGFR in lung adenocarcinomas from Chinese patients was higher than that in western ethnicities. |
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| Keywords: | epidermal growth factor receptor non-small cell lung cancer gene mutation |
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