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Renal clearance of bilirubin conjugates in newborns of different gestational age |
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| Authors: | D. Ullrich T. Tischler A. Sieg J. Fevery |
| Affiliation: | (1) Department of Pacdiatrics, University of Göttingen, Robert-Koch-Strasse 40, D-37075 Göttingen, Germany;(2) Department of Internal Medicine, University of Heidelberg, W-6900 Heidelberg, Germany;(3) Laboratory of Hepatology, Catholic University of Leuven, Belgium;(4) Present address: Department of Ear, Nose, Throat Diseases, Robert-Koch-Strasse 40, D-37075 Göttingen, Germany |
| Abstract: | The renal excretion of bilirubin conjugates was analysed in 22 newborns. Bilirubin monoconjugate was the only metabolite detectable in urine samples and its renal excretion correlated with the creatinine excretion rate (r=0.91). The renal clearance of bilirubin mono-conjugates in newborns ranged between 380 and 2160 ml/1.73 m2 per 24 h (median: 790). According to the present findings the renal function should be monitored in newborns and infants with conjugated hyperbilirubinaemia. |
| Keywords: | Bilirubin conjugates Bilirubin monoconjugates Renal clearance Newborns |
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