Naloxone does not attenuate the locomotor effects of ethanol in FAST,SLOW, or two heterogeneous stocks of mice |
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Authors: | Sarah?E?Holstein Raúl?Pastor Paul?J?Meyer Email author" target="_blank">Tamara?J?PhillipsEmail author |
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Institution: | (1) Portland Alcohol Research Center, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA;(2) Department of Behavioral Neuroscience, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA;(3) Area de Psicobiología, Universitat Jaume I, Campus de Riu Sec, 12071 Castelló, Spain;(4) Veterans Affairs Medical Center, R&D 32, 3710 SW US Veterans Hospital Road, Portland, OR 97239, USA |
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Abstract: | Rationale Previous studies suggest that some behavioral effects of ethanol and morphine are genetically correlated. For example, mice
bred for sensitivity (FAST) or insensitivity (SLOW) to the locomotor stimulant effects of ethanol differ in their locomotor
response to morphine.
Objective To evaluate a possible common mechanism for these traits, we examined the effect of naloxone, an opioid receptor antagonist,
on ethanol- and morphine-induced locomotion in FAST and SLOW mice, as well as on ethanol-induced locomotion in two heterogeneous
stocks of mice.
Method In experiments 1 and 2, naloxone was given to FAST and SLOW mice 30 min prior to 2 g/kg ethanol or 32 mg/kg morphine, and
locomotor activity was measured for 15 min (ethanol) or 30 min (morphine). In experiments 3 and 4, naloxone was administered
30 min prior to 1.25 g/kg ethanol, and locomotor activity was assessed in FAST mice and in a heterogeneous line of mice Withdrawal
Seizure Control (WSC)]. Experiment 5 assessed the effect of naloxone on ethanol-induced stimulation in outbred National Institutes
of Health (NIH) Swiss mice.
Results There was no effect of naloxone on the locomotor response to ethanol in FAST, SLOW, WSC, or NIH Swiss mice. However, naloxone
did significantly attenuate the locomotor effects of morphine in FAST and SLOW mice.
Conclusions These results suggest that a common opioidergic mechanism is not responsible for the correlated locomotor responses to ethanol
and morphine in FAST and SLOW mice, and that activation of the endogenous opioid system is not critical for the induction
of ethanol-induced alterations in activity. |
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Keywords: | Alcohol Alcoholism Locomotor activity Stimulation Sedation Opioid receptor Selected lines Pleiotropy |
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