Lactate rise detected by 1H NMR in human visual cortex during physiologic stimulation. |
| |
Authors: | J Prichard D Rothman E Novotny O Petroff T Kuwabara M Avison A Howseman C Hanstock and R Shulman |
| |
Institution: | Department of Neurology, Yale Medical School, New Haven, CT 06510. |
| |
Abstract: | Brain lactate concentration is usually assumed to be stable except when pathologic conditions cause a mismatch between glycolysis and respiration. Using newly developed 1H NMR spectroscopic techniques that allow measurement of lactate in vivo, we detected lactate elevations of 0.3-0.9 mM in human visual cortex during physiologic photic stimulation. The maximum rise appeared in the first few minutes; thereafter lactate concentration declined while stimulation continued. The results are consistent with a transient excess of glycolysis over respiration in the visual cortex, occurring as a normal response to stimulation in the physiologic range. |
| |
Keywords: | |
|
|