| 急性心肌梗死患者脂蛋白脂肪酶基因Ser447Stop的多态性研究 |
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| 引用本文： | 邹宏丽,宋玉强,王文.急性心肌梗死患者脂蛋白脂肪酶基因Ser447Stop的多态性研究[J].山东医药,2008,48(7):7-9. |
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| 作者姓名： | 邹宏丽 宋玉强 王文 |
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| 作者单位： | 1. 青岛大学医学院第二附属医院,山东青岛,266042
2. 青岛大学医学院附属医院 |
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| 摘 要： | 目的 探讨中国人群中脂蛋白脂肪酶基因Ser447Stop多态性与急性心肌梗死的相关性.方法 应用PCR和限制性片段长度多态性分析的方法测定86例急性心肌梗死患者和90例对照组脂蛋白脂肪酶基因Ser447Stop多态性.结果 急性心肌梗死组的CG GG基因型频率显著低于对照组(分别为0.174和0.422,P<0.05).急性心肌梗死组的G等位基因频率为0.087,亦显著低于对照组的0.217.急性心肌梗死亚组间的分析显示,血脂异常组CG GG基因型与G等位基因频率均显著低于血脂正常组(P<0.05).结论 脂蛋白脂肪酶基因Ser447Stop多态性与急性心肌梗死有一定的相关性,G等位基因可能是急性心肌梗死的一个保护性因素.
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| 关 键 词： | 脂蛋白脂肪酶 心肌梗死 急性 Ser447Stop 多态性 |
Relationship between Ser447Stop polymorphism of lipoprotein lipase gene and acute myocardial infarction |
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| ZOU Hong-li,SONG Yu-qiang,WANG Wen.Relationship between Ser447Stop polymorphism of lipoprotein lipase gene and acute myocardial infarction[J].Shandong Medical Journal,2008,48(7):7-9. |
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| Authors: | ZOU Hong-li SONG Yu-qiang WANG Wen |
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| Institution: | ZOU Hong-li1,SONG Yu-qiang,WANG Wen (1 Second Affiliated Hospital of Medical College,Qingdao University,Qingdao 266042,P.R.China) |
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| Abstract: | Objective To investigate the relationship between Ser447Stop polymorphism of LPL and acute myocardial infarction(AMI) in Chinese patients.Methods 86 AMI patients and 90 control subjects were recruited and the Ser447Stop polymorphism of LPL gene was analyzed by polymerase chain reaction and restriction fragment length polymorphism(PCR-RFLP).Results The CG+GG genotype frequencies in the AMI group and control group were 0.174 and 0.422,respectively.The prevalence of the CG+GG genotype was significantly lower i... |
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| Keywords: | lipoprotein lipase myocardial infarction acute Ser447Stop polymorphism |
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