| B7-H1在慢性乙型肝炎肝组织中的表达及临床意义 |
| |
| 引用本文： | 孙趁意,唐芙爱,刘占举.B7-H1在慢性乙型肝炎肝组织中的表达及临床意义[J].河南科技大学学报(医学版),2008,26(2). |
| |
| 作者姓名： | 孙趁意 唐芙爱 刘占举 |
| |
| 作者单位： | 郑州大学第二附属医院消化内科,河南郑州,450014 |
| |
| 基金项目： | 河南省卫生厅科技攻关项目 |
| |
| 摘 要： | 目的 研究共刺激分子B7-H1在慢性乙型肝炎(chronic hepatitis B,CHB)肝组织中的表达及临床意义.方法 采用免疫组织化学和半定量逆转录聚合酶链反应(RT-PCR)检测30例CHB肝组织中B7-H1蛋白和mRNA的表达.结果 30例CHB肝组织中18例(60%)肝组织中B7-H1表达阳性,11例正常人肝组织无表达.B7-H1分子的表达与肝组织炎症活动程度及纤维化进程密切相关.RT-PCR结果与其一致.结论 B7-H1在慢性乙型肝炎感染者中明显增高,并与肝组织炎症活动程度相关,提示B7-H1在慢性乙型肝炎中担负着重要的免疫调节作用,可成为判断乙肝活动强弱的一个指标.
|
| 关 键 词： | 慢性乙型肝炎 炎症 纤维化 |
Expression and Clinical Significance of B7-H1 in Chronic Hepatitis B |
| |
| SUN Chen-yi,TANG Fu-ai,LIU Zhan-ju.Expression and Clinical Significance of B7-H1 in Chronic Hepatitis B[J].Journal of Henan University of Science & Technology:Medical Science,2008,26(2). |
| |
| Authors: | SUN Chen-yi TANG Fu-ai LIU Zhan-ju |
| |
| Institution: | SUN Chen-yi,TANG Fu-ai,LIU Zhan-ju(Second Affiliated Hospital,Zhengzhou University,Zhengzhou 450014,China) |
| |
| Abstract: | Objective To study the expression of B7-H1 mRNA and B7-H1 protein in liver tissue of patients with chronic hepatitis B(CHB),and investigate its relevance to the pathogenesis. Methods The B7-H1 mRNA and B7-H1 protein expression were determined in liver tissues from 30 CHB patients and 11 healthy controls using immunohistochemistry assay and real-time PCR(RT-PCR). Results B7-H1 expression was found to be 60%(18/30) of liver specimens in CHB patients,but none in 11 normal controls(P<0.05).B7-H1 expression was ... |
| |
| Keywords: | B7-H1 |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
