Diet,cow's milk protein antibodies and the risk of IDDM in Finnish children |
| |
| Authors: | Dr. S. M. Virtanen T. Saukkonen E. Savilahti K. Ylönen L. Räsänen A. Aro M. Knip J. Tuomilehto H. K. Åkerblom R. Lounamaa L. Toivanen E. A. Kaprio J. Pitkäniemi E. Virtala A. Fagerlund M. v. Flittner B. Gustafsson C. Häggqvist A. Hakulinen L. Herva P. Hiltunen T. Huhtamäki N. -P. Huttunen T. Huupponen M. Hyttinen T. Joki R. Jokisalo M. -L. Käär S. Kallio U. Kaski L. Laine J. Lappalainen J. Mäenpää A. -L. Mäkelä K. Niemi A. Niiranen P. Ojajärvi T. Otonkoski K. Pihlajamäki S. Pöntynen J. Rajantie J. Sankala J. Schumacher M. Sillanpää M. -R. Ståhlberg C. -H. Stråhlmann T. Uotila M. Väre P. Varimo |
| |
| Affiliation: | (1) Division of Nutrition, Department of Applied Chemistry and Microbiology and the Children's Hospital, University of Helsinki, Helsinki, Finland;(2) Second Department of Pediatrics, University of Helsinki, Helsinki, Finland;(3) First Department of Pediatrics, University of Helsinki, Helsinki, Finland;(4) Department of Nutrition, National Public Health Institute, Helsinki, Finland;(5) Department of Epidemiology and Health Promotion, National Public Health Institute, Helsinki, Finland;(6) Department of Paediatrics, University of Oulu, Oulu, Finland |
| |
| Abstract: | Summary Associations of infant feeding patterns and milk consumption with cow's milk protein antibody titres were studied in 697 newly-diagnosed diabetic children, 415 sibling-control children and 86 birth-date-and sex-matched population-based control children in the nationwide  Childhood Diabetes in Finland study. IgA and IgG antibody titres to the proteins of cow's milk formula, BLG and BSA, and IgM antibody titres to cow's milk formula proteins were measured by ELISA. Several inverse correlations were observed between the duration of breast-feeding or age at introduction of dairy products and antibody titres, and positive correlations were observed between milk consumption and antibody titres in all three populations studied. Multivariate analyses which included the infant feeding variables, milk consumption and current age simultaneously showed that the earlier the introduction of dairy products and the greater the consumption of milk was, the higher several antibody titres were. High IgA antibody titres to cow's milk formula were associated with a greater risk of IDDM both among diabeticpopulation-control and diabetic-sibling-control pairs when adjusted for other cow's milk antibody titres, dietary variables and in diabetic-sibling-control pairs also for ICA. The results suggest that young age at introduction of dairy products and high milk consumption during childhood increase the levels of cow's milk antibodies and that high IgA antibodies to cow's milk formula are independently associated with increased risk of IDDM.Abbreviations IDDM Insulin-dependent diabetes mellitus - BLG betalactoglobulin - BSA bovine serum albumin - ICA islet cell antibodies - IAA insulin autoantibodies - OR odds ratio - CI confidence interval |
| |
| Keywords: | Infant feeding dairy products cow's milk protein antibodies IDDM childhood islet cell antibodies insulin autoantibodies |
| 本文献已被 SpringerLink 等数据库收录！ |
|
