Preparation and radiolabeling of antimony sulfide nanocolloids with two different particle sizes

Antimony sulfide nanocolloids with two different particle sizes were prepared by a modified traditional method and a new method. Transmission electron microscope (TEM) showed the mean particle sizes to be 10.2±2.3 and 44.7±13.8 nm, respectively. The nanocolloids were then radiolabeled with ^99mTc, or with ¹⁸⁸Re. The labeling yields of ^99mTc-Sb₂S₃ (10.2±2.3 nm and 44.7±13.8 nm)>98% and >96% for ¹⁸⁸Re-Sb₂S₃ (10.2±2.3 and 44.7±13.8 nm). The stability of the labeled products was studied at room temperature and all showed excellent stability except for ¹⁸⁸Re-Sb₂S₃ (10.2±2.3 nm). The mechanism of labeling of nanocolloids with ¹⁸⁸Re is different from that of ^99mTc. The antimony sulfide nanocollides prepared by the new method, after labeling are expected to have diagnostic or therapeutic potential in nuclear medicine.