Age and fertility

More women are planning pregnancy after the age of 35. Unfortunately for these individuals, aging is associated with compromised ovarian function and decreasing fecundity. Compromised oocyte quality is associated with fetal aneuploidies and poor quality embryos with an increased miscarriage rate. Secondary to this compromised oocyte quality, success rates of assisted reproductive techniques decline. Follicle stimulating hormone (FSH) and estradiol levels on day 3 of the menstrual cycle help to assess the ovarian reserve. Fertility potential can also be assessed by the clomiphene challenge test. In order for women to plan for their childbearing, an understanding of the influence of age on fertility is essential. It is the responsibility of caregivers to educate patients regarding this issue. Assisted reproductive techniques (ART), ovum donation, and preimplantation diagnostic techniques help to improve the successful pregnancy outcomes in older women.