| 肾八味胶囊对肾病综合征模型小鼠血清IL-6的影响 |
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| 引用本文： | 桑素珍,沈惠风,部帅.肾八味胶囊对肾病综合征模型小鼠血清IL-6的影响[J].山东中医药大学学报,2010(3). |
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| 作者姓名： | 桑素珍 沈惠风 部帅 |
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| 作者单位： | 上海交通大学医学院附属仁济医院中医科;山东中医药大学; |
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| 基金项目： | 上海市卫生局科研课题(编号:2006035) |
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| 摘 要： | 目的:观察肾八味胶囊对肾病综合征(NS)模型小鼠24h尿蛋白和血清白介素6(IL-6)的影响,以探讨该方对NS的免疫治疗作用机制。方法:给小鼠一次性尾静脉注射嘌呤霉素氨基核苷(Puromycin aminonucleoside,PA)复制NS模型,40只小鼠随机分为模型组、肾八味低剂量组、肾八味高剂量组、至灵胶囊组、生理盐水组,采用BCA法检测各组小鼠24h尿蛋白,采用酶联免疫吸附法检测小鼠血清IL-6的含量。结果:模型组小鼠24h尿蛋白和血清IL-6均较生理盐水组显著升高,中药灌服后能显著降低NS小鼠24h尿蛋白和血清IL-6的含量。结论:降低血清IL-6的含量可能是肾八味胶囊治疗NS的作用机制之一。
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| 关 键 词： | 肾八味胶囊 嘌呤霉素氨基核苷 肾病综合征 白介素6 实验研究 |
Effect of Shenbawei capsule on serum IL-6 of mice with nephrotic syndrome |
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| SANG Su-zhen,SHEN Hui-feng,BU Shuai.Effect of Shenbawei capsule on serum IL-6 of mice with nephrotic syndrome[J].Journal of Shandong University of Traditional Chinese Medicine,2010(3). |
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| Authors: | SANG Su-zhen SHEN Hui-feng BU Shuai |
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| Institution: | SANG Su-zhen1,SHEN Hui-feng1,BU Shuai2(1.Traditional Chinese Medicine Devision,Renji Hospital Affiliated to Medicine College,Shanghai Jiaotong University,Shanghai 200127,China,2.Sh,ong University of Traditional Chinese Medicine,Jinan 250355,China) |
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| Abstract: | Objective:To explore the immune mechanism of Shenbawei capsule to treat nephrotic syndrome(NS) by observing 24 h urinary protein and serum interleukin-6(IL-6) of mice.Methods:Each mouse was given a single intravenous injection with puromycin aminonucleoside(PA) to make NS model.Fouty mice were randomly divided into 5 groups:model group,low-dose Shenbawei group,high-dose Shenbawei group,normal saline group,Zhiling capsule group.The 24 h urinary protein were measured by bicinchoninic acid assay(BCA) and conte... |
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| Keywords: | Shenbawei capsule puromycin aminonucleoside nephritic syndrome interleukin-6 experimental study |
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