α-干扰素治疗病毒性肝炎不良反应的分析

目的　进一步认识α-干扰素治疗病毒性肝炎中出现的常见和严重不良反应,提示临床中长期应用α-干扰素应注意的问题。方法　收集国内医药期刊上公开发表的关于α-干扰素治疗病毒性肝炎时不良反应的报道,并进行统计分析和归纳。结果　文献涉及不良反应5 89例次,用药初期多为流感样症状,反复多次用药后不良反应可累及多个器官和系统。结论　α-干扰素治疗病毒性肝炎中会出现多种不良反应并随着剂量累积或治疗时间的延长而出现一些较严重的不良反应,临床中应加强用药监测,积极预防并对症处理。

Analysis of Adverse Reaction by a-interferon in Treatment of Viral Hepatitis

Objective To understand more adverse reactions by a-interferon in treatment of viral hepatitis. Methods 18 literatures about adverse reaction by a-interferon were collected and reviewed from national medical journals. Results 539 cases with adverse reactions were reported. In the initial stage of the therapy the common reaction was flu-like symptoms and after a-interferon was repeatedly taken, many organs/systems were involved. Conclusion There were many adverse reactions in treatment of viral hepatitis by a-interferon, and even some severe reactions may arise from taking interferon with a large dose for a long time. So some clinical precautions should be taken in order to prevent and reduce the adverse reaction.