强化生活方式联合药物干预对中老年骨量减少的疗效分析

目的评价强化生活方式联合药物干预中老年骨量减少患者的临床效果。方法将50～65岁的210名中老年骨量减少患者随机分为强化生活方式联合药物组（即干预组）和对照组,干预组措施包括有氧运动（快走或慢跑30min～1h,舒展体操10min,每周4～5次）,每天补充钙尔奇D1片（含元素钙600mg,维生素D125IU）;对照组对生活方式无特殊要求。分别于干预前、干预后12个月时测量腰椎（L1～4）和左侧股骨颈骨密度。结果干预组1年后腰椎BMD有显著升高,而股骨颈BMD无明显变化;对照组腰椎BMD和股骨颈BMD均明显下降。结论强化生活方式联合药物治疗可以有效地防止和延缓中老年骨量减少患者的骨量丢失,增加骨密度。

The Analysis of the Efficacy of Intensive Lifestyle and Drug Intervention on BMD of Osteopenia in the Elderly

Objective To evaluate the clinical effectiveness of intensive lifestyle and drug intervention on BMD of osteopenia in the elderly. Methods 210 elderly people aged 50～65 years were randomly divided into the intervention group （intensive lifestyle combined drug intervention group） and the control group. The intervention group were required to do aerobic exercises, such as fast walking or jogging for 30 minutes～1hour, stretch gymnastics for 10 minutes, 4～5 times a week and take one tablet of Caltrate D, which including calcium 600 mg and vitamin D125IU, every day. The control group received no special requirements in their life. BMD of lumbar spine （L1～4） and the left femoral neck were measured respectively by DXA before and after 12-month intervention. Results After one-year intervention, the BMD of lumbar spine of the intervention group significantly increased, but the femoral neck BMD had no obvious change. The lumbar BMD and the femoral neck BMD of the control group decreased significantly. Conclusion Intensive lifestyle combined with drug therapy can effectively prevent and delay bone loss and increase bone density of elderly patients with osteopenia.