天保康注射液抗血管内皮细胞功能氧化损伤治疗缺血性中风的临床研究

目的：探讨天保康注射液治疗缺血性中风的临床疗效及治疗机制。方法：70例缺血性中风患者随机分为天保康治疗组（38例）和西药对照组（32例），进行两组临床疗效观察和比较，并检测血液流变学指标，血浆SOD活性采用微量快速测定法，MDA含量测定采用改良八木国夫法，血清ET－1的测定采用放射免疫法（RIA），NO的测定采用化学比色法。结果：天保康治疗缺血性中风患者总有效率为92．1％；且能改善血液流变学指标，降低MDA、ET－1，升高SOD、NO水平，与对照组无显著差异（P＞0．05）。结论：天保康注射液对缺血性中风患者有较好的治疗效果，其治疗的机制可能与改善血液流变性、抗脂质过氧化损伤和抗血管内皮损伤等作用有关。

Clinical Study on Tianbaokang Injection against Oxidative Injury of Vascular Endothelial Function in Ischemic Apoplexy

Objective:To discuss clinical effects and therapeutic mechanisms of Tianbaokang Injection on ischemic apoplexy. Methods:70 cases of ischemic apoplexy were divided into two groups at random(Tianbaokang group and contrast group,38 and 32 cases respectively). Clinical effects and indexes of hemorheology and vascular endothelial oxidative injury (SOD activity, MDA content, NO level and ET-1 concentration). Results: The efficiency of Tianbaokang on ischemic apoplexy was 92.1% .Tianbaokang can improve indexes of hemorheology, decrease plasm MDA and ET-1 content, and increase SOD activity and NO level obviously. Conclusion: Tianbaokang has better effects on ischemic apoplexy.The therapeutic mechanisms may be related to improving hemorheology, inhibiting lipid peroxidation and vascular endothelial injury, and regulating endothelial function.