| 肝素诱导的血小板减少症研究进展 |
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| 引用本文： | 章岱.肝素诱导的血小板减少症研究进展[J].心血管病学进展,2010,31(5):681-684. |
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| 作者姓名： | 章岱 |
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| 作者单位： | 首都医科大学附属北京友谊医院心血管中心,北京,100050 |
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| 摘 要： | 肝素诱导的血小板减少症是一种特异性自身免疫性疾病,是由于抗体对肝素-血小板因子4复合物的识别,损伤了血小板以及内皮细胞而导致,以血小板减少及血栓形成为主要表现,通过4T评分以及实验室检查可有助于诊断,治疗上需要立即停用肝素及其相关制剂并开始替代抗凝治疗。
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| 关 键 词： | 肝素 血小板减少症 |
Advances in Heparin Induced Thrombocytopenia |
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| ZHANG Dai.Advances in Heparin Induced Thrombocytopenia[J].Advances in Cardiovascular Diseases,2010,31(5):681-684. |
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| Authors: | ZHANG Dai |
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| Institution: | ZHANG Dai,WANG Lei(Cardiovascular Center of Beijing Friendship Hospital,Capital Medical University,Beijing 100050,China) |
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| Abstract: | Heparin-induced thrombocytopenia（HIT） is an immune-mediated hypercoagulable disorder caused by antibodies to platelet factor 4（PF4）and heparin.The antibody-heparin-PF4 complexes injure platelet and endothelial cell,cause thrombocytopenia and thrombosis.The 4Ts clinical scoring system and some laboratory tests can help us to diagnose HIT.The treatment include stop using heparin immediately and initiate alternative anticoagulant therapy. |
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| Keywords: | heparin thrombocytopenia |
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