| 阿苯达唑自微乳大鼠在体肠吸收研究 |
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| 引用本文： | 王科燕,张永军,樊莲莲,魏丽红. 阿苯达唑自微乳大鼠在体肠吸收研究[J]. 西北药学杂志, 2009, 24(5): 375-376 |
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| 作者姓名： | 王科燕 张永军 樊莲莲 魏丽红 |
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| 作者单位： | 1. 石河子大学药学院,新疆,石河子,832002
2. 石河子大学第一附属医院,新疆,石河子,832002 |
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| 基金项目： | 新疆生产建设兵团医药资助项目 |
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| 摘 要： | 目的研究阿苯达唑自微乳在小肠各部位的吸收情况。方法采用大鼠在体肠单向灌流实验,RP-HPLC法测定药物浓度,根据药物进出小肠各段中的质量减少量来求算出药物的吸收速率。结果在十二指肠、空肠、回肠中的吸收速率常数依次是1.78×10-2,2.15×10-2和1.25×10-2·min-1。结论阿苯达唑自微乳在整个小肠段都有吸收,且小肠中段吸收较好。
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| 关 键 词： | 阿苯达唑 自微乳 单向灌流法 在体小肠吸收 |
Study on in situ intestinal absorption of albendazole self-microemulsion in rats |
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| Abstract: | Objective To investigate the absorption of albendazole self-microemulsion in rats.Methods The single-pass intestinal model was used and the concentrations of albendazole were determined by RP-HPLC.Results The absorption rate constants(Ka) of albendazole self-microemulsion at the ileum,jejunum,and duodenum were 1.78×10-2,2.15×10-2 and 1.25×10-2·min-1,respectively.Conclusion Albendazole was absorbed at the entire intestine and well absorption was at the middle segment of intestine in rats. |
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| Keywords: | albendazole self-microemulsion single-pass intestinal perfusion in situ intestinal absorption |
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