| 氯氮平某些副作用对疗效的预测 |
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| 引用本文： | 喻东山,张心保,蒋晓军,孙旦辉,肖红,张石宁. 氯氮平某些副作用对疗效的预测[J]. 上海精神医学, 1999, 11(3): 138-139,157 |
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| 作者姓名： | 喻东山 张心保 蒋晓军 孙旦辉 肖红 张石宁 |
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| 作者单位： | 南京医科大学附属脑科医院 210029(喻东山，张心保，蒋晓军，孙旦辉，肖红)，南京医科大学附属脑科医院 210029(张石宁) |
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| 摘 要： | 目的 探索氯氮平治疗第4周末副作用与疗效的关系。方法 给66例精神分裂症患者单服氯氮平,并且评价了0和4周的PANSS,4周的TESS和氯氮平血清浓度。结果 4周TESS的抗5-羟色胺因子分与4周PANSS总分减分率有显著负相关(r=-0.3095,P<0.05),抗5-羟色胺因子分在窗内(1～4分)的显效率17/30比窗外的8/36显著为高x~2=6.862),P<001),相反,氯氟平血清浓度与疗效无显著相关(r=0.1787,P>0.05人氯氮平血清浓度的窗内(200～400μg/L)显效率23/49与窗外2/14无显著差异(x~2=3.592,P>0.05)。结论 4周抗5-羟色胺因子分治疗窗优于4周血药浓度治疗窗。
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| 关 键 词： | 氯氮平 副作用 疗效 血药浓度 治疗窗 |
An association of the efficacy of clozapine with its side effects. |
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| Yu Dongshan,Zhang Xinbao,Jiang Xiaojun,el al. An association of the efficacy of clozapine with its side effects.[J]. Shanghai Archives of Psychiatry, 1999, 11(3): 138-139,157 |
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| Authors: | Yu Dongshan Zhang Xinbao Jiang Xiaojun el al |
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| Affiliation: | Yu Dongshan,Zhang Xinbao,Jiang Xiaojun,el al. The Affiliated Brain Hospital of Nanjing Medical University. Nanjing 210029 |
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| Abstract: | Objective: To explore the relationship between efficacy of clozapine and its side effects. Method: PANSS, TESS and serum clozapine level were evaluated in 66 schizophrenics taking clozapine alone. Results: There was a negative correlation between anti-serotonin factor score of TESS at 28th day and cliical improvement (r =-0.3095, P<0.05), improvement rate was higher within the therapeutic window of anti-serotonin factor score (1- 4) than outside the window (x2 = 6.862, P<0.01), and no signficant correlation was found between clinical improvement and serum clozapine level (r - 0.1787, P > 0.05). Conclusion: The efficacy of clozapine was correlated to therapeutic window of anti-serotonin factor score in TESS. |
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| Keywords: | Clozapine Side effect Efficacy Serum drug level Therapeutic window |
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