| 黑米皮抑制apoE基因缺陷小鼠T淋巴细胞表达 |
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| 引用本文： | 夏敏,朱惠莲,唐志红,马静,凌文华. 黑米皮抑制apoE基因缺陷小鼠T淋巴细胞表达[J]. 中国公共卫生, 2004, 20(3): 266-267 |
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| 作者姓名： | 夏敏 朱惠莲 唐志红 马静 凌文华 |
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| 作者单位： | 中山大学公共卫生学院营养系,广州,510080 |
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| 基金项目： | 国家自然科学基金杰出青年基金资助( 30 0 2 50 37) |
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| 摘 要： | 目的 研究黑米皮对载脂蛋白E(apoE)基因缺陷小鼠主动脉窦CD4^ 和CD8^ T淋巴细胞表达的影响，探讨黑米皮抗动脉粥样硬化(AS)作用的机制。方法 选用apoE基因缺陷小鼠进行实验，通过在apoE基因缺陷小鼠普通饲料AIN-93中添加5％黑米皮，检测apoE基因缺陷小鼠主动脉窦动脉粥样斑块面积和CD4^ 、CD8^ T淋巴细胞表达的水平。结果黑米皮可降低apoE基因缺陷小鼠主动脉窦动脉粥样斑块面积以及CD4^ T淋巴细胞表达的水平。结论 黑米皮的抗AS作用与其抑制CD4^ T淋巴细胞表达有关。
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| 关 键 词： | 黑米皮 载脂蛋白E基因缺陷小鼠 T淋巴细胞 |
| 文章编号： | 1001-0580(2004)03-0266-02 |
| 修稿时间： | 2003-06-16 |
Inhibiting function of BRF on T lymphocyte expression in apolipoprotein E deficient mice |
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| XIA Min,ZHU Hui-lian,TANG Zhi-hong,et al.. Inhibiting function of BRF on T lymphocyte expression in apolipoprotein E deficient mice[J]. Chinese Journal of Public Health, 2004, 20(3): 266-267 |
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| Authors: | XIA Min ZHU Hui-lian TANG Zhi-hong et al. |
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| Affiliation: | XIA Min,ZHU Hui-lian,TANG Zhi-hong,et al.Schoo l of Public Health,Zhongshan University |
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| Abstract: | ObjectiveTo explore the effect of black rice outer layer fraction (BRF) on CD -4 T,CD -8 T lymphocyte expression in apoE-deficien t mice and find the possible mechanism of BRF in anti-atherogenesis. MethodsCD -4 T and CD -8 T lymphocyte expression i n aortic sinus and atherosclerotic lesion area in aortic sinus were assessed by immunohistochemistry and image analysis,respectively. ResultsBRF inhibited CD -4 T lymphocyte expression an d atherosclerotic lesion area in aortic sinus. ConclusionBRF dramatically reduced CD -4 T lymphocyte expression and this effect maybe related to its anti-atherogenesis. |
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| Keywords: | black rice outlayer fraction apolipoprotein E- deficient mice T lymphocyte |
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