Transepidermal water loss and absorption of hydrocortisone in widespread dermatitis |
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Authors: | K. AALTO-KORTE M. TURPEINEN |
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Affiliation: | Department of Skin and Allergic Diseases, University Central Hospital Meilahdentie 2, 00250 Helsinki, Finland |
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Abstract: | Percutaneous absorption of hydrocortisone was measured in tbree children and six adults with widespread dermatitis, after the application of 1% bydrocortisone cream. Before appiication of the cream, the transepidermal water loss (TEWL) was measured on six skin areas. A highly significant correlation was found between the post-application rise in plasma cortisol level and the mean transepidermal water loss. Thus, measurement of TEWL affords a simple, non-invasive method for assessing the systemic effect of hydrocortisone applied to widespread dermatitis. |
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