2型糖尿病患者非糖尿病一级亲属血清高敏C反应蛋白与胰岛素抵抗的相关性 |
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引用本文: | 邓晨昕,高凌,张海荣,曾照琼. 2型糖尿病患者非糖尿病一级亲属血清高敏C反应蛋白与胰岛素抵抗的相关性[J]. 中华糖尿病杂志, 2008, 16(7): 413-415 |
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作者姓名: | 邓晨昕 高凌 张海荣 曾照琼 |
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作者单位: | [1]襄樊市中心医院内分泌科,湖北441021 [2]襄樊市中心医院检验科,湖北441021 |
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摘 要: | 目的探讨血清高敏C反应蛋白(hsC-RP)在2型糖尿病(T2DM)发病中的作用。方法利用ELISA方法检测72例T2DM患者非糖尿病一级亲属(FDR)和68例健康对照者(NC)血清hsC-RP、Fins、FPG等,并用HOMA—IR公式计算胰岛素抵抗指数。结果(1)FDR组血清hsC—RP水平较NC组升高(P〈0.01),HOMA—IR高于NC组(P〈0.01);(2)血清hsC-RP水平与HOMA-IR(r=0.307,P〈0.01)、Fins(r=0.286,P〈0.05)、BMI(r=0.250,P〈0.05)、LDL—C(r=0.302,P〈0.05)、TC(r=0.267,P〈0.05)相关。结论慢性炎症与胰岛素抵抗密切相关,hsC-RP升高是2型糖尿病发生的一个预测因子。
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关 键 词: | 糖尿病 C反应蛋白 胰岛素抵抗 |
Relation of high-sensitivity C-reactive protein with insulin resistance in the first-degree relatives of type 2 diabetics |
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Affiliation: | DENG Chen-xin , GAO Ling, ZHANG Hai-rong , et al. (Department of Endocrinology, Xiang-fan Central Hospital, Affiliated to Tongji Medical College , Huazhong University of Science and Technology, Xiangfan 441021, China) |
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Abstract: | Objective To explore the possible pathogenesis of type 2 diabetes. Methods Serum samples were collected from 72 first-degree relatives of type 2 diabetic subjects and 68 normal subjects. Results Circulation levels of high-sensitivity C-reactive protein (hsCRP) and insulin resistance index estimated by homeostasis model assessment (HOMA-IR) were significantly higher in first-degree relatives than in controls (P 〈 0.01). Circulation levels of hsCRP was correlated to HOMA-IR (r = 0. 307, P 0.01) ,fasting insulin (Fins) (r=0. 286,P〈0. 05), body mass index (BMI) (r=0. 250, P〈0.05) ,low-density lipoprotein cholesterol (LDL-C) (r=0. 302, P〈0.05) and total cholesterol(TC) (r=0. 267, P〈 0.05). Conclusions The data support the hypothesis that low-grade systemic inflammation is associated with insulin resistance, hsCRP is a strong predictor for the development of type 2 diabetes. |
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Keywords: | Diabetes mellitus C-reactive protein Insulin resistance |
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